In order to improve the solubility and the long-cycle performance of hydrophobic drug sorafenib (SOR), and to obtain an ideal smart drug delivery system for the effective treatment of liver cancer, S-SMIP, a pH/GSH double-sensitive sorafenib stealth imprinting material, was successfully prepared by UV-initiated surface imprinted polymerization on the basis of polyethylene glycol 2000 (PEG 2000 ) acted as "gate keeper" modified magnetic substrate. The results showed that S-SMIP had a good adsorption capacity of 260.0 mg g À1 and an excellent selectivity factor α 2.33. S-SMIP's kinetic adsorption data accorded well with the pseudo-second-order model and its mechanism was controlled mainly by chemical adsorption. The drug release experiments in vitro indicated S-SMIP could not only greatly improve the solubility of SOR, but also had the pH/GSH dual-sensitive response performance. Compared with the non-stealth imprinted material SMIP, S-SMIP still had a better long-cycle effect on the release of SOR, increasing to160 h from 130 h. So, the target material S-SMIP could greatly prolong the half-life of SOR, which provided a good idea for the development of a smart drug delivery system.

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