In this study, we constructed novel brain-targeting complexes (U2-AuNP) by conjugating aptamer U2 to the gold nanoparticle (AuNPs) surface as a promising option for GBM therapy. Materials and Methods: The properties of the U2-AuNP complexes were thoroughly characterized. Then, we detected the in vitro effects of U2-AuNP in U87-EGFRvIII cell lines and the in vivo antitumor effects of U2-AuNP in GBM-bearing mice. Furthermore, we explored the inhibition mechanism of U2-AuNP in U87-EGFRvIII cell lines. Results: We found that U2-AuNP inhibits the proliferation and invasion of U87-EGFRvIII cell lines and prolongs the survival time of GBM-bearing mice. We found that U2-AuNP can inhibit the EGFR-related pathway and prevent DNA damage repair in GBM cells. Conclusion: These results reveal the promising potential of U2-AuNP as a drug candidate for targeted therapy in GBM.

The relationship between oviposition preference and offspring performance is critical to an understanding of the interaction between herbivores and host plants. Although the topic has been addressed widely in plant species‐herbivore systems, it has rarely been investigated in plant stage‐herbivore systems. In this study, we evaluated oviposition preference and offspring performance of the rice leaf folder (RLF), Cnaphalocrocis medinalis (Guenée) (Lepidoptera: Pyralidae), on rice plants at the seedling (SS), tillering (TS), and booting (BS) stages. In preference assays, females deposited more eggs on TS and BS than on SS plants in cage tests, and preferred TS and BS odors over SS odors in Y‐tube olfactometer tests. Offspring performance was affected by plant stage. The RLF offspring performed well when the larvae fed on BS leaves, as indicated by the highest larval survival and pupation rate and the greatest adult longevity. RLF offspring performed also well when the larvae fed on TS leaves, where fecundity was the highest. The high RLF offspring performance on TS and BS plants coincided with high larval consumption of TS and BS leaf mass relative to SS leaf mass. Our findings confirm the prediction of the preference–performance hypothesis. The results explain the pest damage patterns in mixed croppings of one‐ and two‐season rice and are of significance for management of the pest through synchronization of rice planting.

Low-temperature storage (LTS) is a way to adjust natural enemy development to meet field release needs and to protect natural enemies from the odds of long-distance transportation. The mirid bug Cyrtorhinus lividipennis Reuter (Hemiptera: Miridae) is an important predator of planthoppers and leafhoppers in rice fields. In this study, the LTS effects were measured on the predatory capacity and reproduction of the mirid adults (provided with 20% honey solution and stored at 13 °C for 12 days), and the fitness of the F1 generation of these adults. Higher predation of the eggs of the brown planthopper Nilaparvata lugens (Stål) (Hemiptera: Delphacidae) was observed in the post-storage females than in the control females. The functional responses of C. lividipennis adults, either exposed to LTS or not, to planthopper eggs fitted well with Holling type II functional responses. Longevity was not affected by LTS, whereas the number of offspring nymphs was 55.6% lower in the post-storage females than in the control females. The fitness of the offspring generation was not affected by the LTS of parental adults. The findings are discussed with their relevance to biological control.