BackgroundChildren with Henoch‐Schonlein purpura nephritis are frequently burdened with psychological problems besides disease treatment and adherence. Currently, there is a shortage of appropriate and effective educational materials to facilitate physical and psychological recovery.ObjectivesTo examine a picture book for the effectiveness of disease‐related knowledge, coping strategies, resilience, quality of life and depressive symptoms in children with Henoch‐Schonlein purpura nephritis in China.DesignA quasi‐experimental design with repeated measures was adopted. The control group received standard care. The intervention group received the standard care plus a free picture book. This disease‐specific picture book narrated the story of two rabbits diagnosed with Henoch‐Schonlein purpura nephritis who underwent a series of examinations, faced difficulties taking medication, and eventually recovered.ParticipantsThe study recruited 60 children diagnosed with Henoch‐Schonlein purpura nephritis.MeasurementsDisease‐related knowledge, resilience, coping strategies, depression and paediatric quality of life were measured at baseline, the third day, the first month and the third month after recruitment. The acceptability of the picture book was evaluated at the last data‐collection point.ResultsThe data showed that children in the intervention group demonstrated higher levels of knowledge (p < 0.001), less usage of emotional coping strategies (p = 0.003), reduced depressive symptoms (p = 0.003), improved psychological resilience (p < 0.001), and better quality of life (p < 0.046) than those in the control group in the third month. Most children (83.3%) in the intervention group were satisfied with the picture book.ConclusionsThe targeted picture book is an effective educational tool for improving clinical outcomes and was highly accepted by children.

Objective: This study aims to provide an overview of meta-analyses and systematic reviews on the effectiveness and safety of immunosuppressive drug therapy for neuromyelitis optica spectrum disorders (NMOSD) by evaluating the methodological quality and reporting quality of reviews. Methods: The Chinese National Knowledge Infrastructure (CNKI), WanFang Data, China Science and Technology Journal Database, Web of Science, the Cochrane Library, PubMed, and Embase databases were searched to collect systematic reviews or meta-analyses on the effectiveness and safety of immunosuppressive therapy for NMOSD from inception to December 2, 2021. Two researchers independently screened reviews and extracted data. Any differences in the procession of review assessment between the two researchers were re-evaluated, and the disagreement was resolved by discussion with other researchers. The following data were extracted: author, year of publication, the country where the study was conducted, study type, the number of included studies, sample size, risk bias tools, medication of immunosuppressive therapy, and main outcomes. Then, the AMSTAR-2, which is a critical appraisal tool for systematic reviews (2nd edition), and Grades of Recommendation, Assessment, Development and Evaluation (GRADE) were used to evaluate the methodological quality and reporting quality of evidence. A comprehensive analysis was conducted on the outcomes for all included reviews. Results: A total of 15 reviews were included. Of the included reviews, 3 were systematic reviews, 7 were meta-analyses, and 5 were systematic reviews and meta- analyses. According to the AMSTAR-2 criteria, 6 studies had high quality, 1 study had moderate quality, 4 studies had low quality, and 4 studies had critically low quality. Based on the GRADE, neither evidence quality for effectiveness nor safety was high. Conclusions: Immunosuppressive drug therapy is effective for patients with NMOSD, but its safety is controversial. Due to the poor quality of evidence, reliability needs to be considered. Thus, large sample, multi-center, double-blind, randomized controlled studies are still needed in the future.

Background: Educational institutions worldwide have experienced the suspension of offline teaching activities in favor of online teaching due to the outbreak of the COVID-19 pandemic. However, few studies have focused on the degree of support for online learning among college students in mainland China. Therefore, the aim of this study was to investigate the degree of support for online learning among Chinese college students during the epidemic and whether depression, loneliness, family communication, and social support were associated factors. Methods: A questionnaire was used to collect cross-sectional data from 9319 college students in mainland China, and a structural equation model was analyzed. Results: The results of the study showed high degrees of support for online learning among Chinese college students during the COVID-19 pandemic, with more than half expressing support. The SEM (Structural Equation Modeling) results showed that depression had a negative and significant effect on college students’ support for online learning (β = −0.07; p < 0.001); family communication had a positive and significant effect on college students’ support for online learning (β = 0.09; p < 0.001); social support had a positive and significant effect on college students’ support for online learning (β = 0.11; p < 0.001). Conclusions: Social support and family communication can alleviate the negative psychological status of college students, and depression plays a mediating role in the effect of social support and family communication on college students’ degree of support for online learning. In addition, a significant chain-mediating effect was found of family communication, loneliness, and depression between social support and college students’ degree of support for online learning. Government and education institutions must focus on college students’ mental health issues and consider family interventions and general support that college students require.

BackgroundDigital health has become a heated topic today and smart homes have received much attention as an important area of digital health. However, most of the existing studies have focused on discussing the impact of smart homes on people or the attitudes of older people towards smart homes. Only few studies have focused on relationship between health-related risks and use of smart homes.AimsTo investigate the association between health-related risks and the use of smart homes, provide new recommendations to promote the implementation of digital health strategies and achieve health for all.MethodsWe used data from 11,031 participants aged 18 and above. The population was clustered based on five health-related risk factors: perceived social support, family health, health literacy, media use, and chronic diseases self-behavioral management. A total of 23 smart homes were categorized into three sub-categories: entertainment smart home, functional smart home, and health smart home. We analyzed demographic characteristics and utilization rate of smart home across different cluster.ResultsThe participants were clustered into three groups: low risk, meddle risk, and high risk. The utilization rate of smart home was the most popular in the low risk group (total smart home: 86.97%; entertainment smart home: 61.07%, functional smart home: 77.42%, and health smart home: 75.33%; p < 0.001). For entertainment smart home, smart TV had the highest utilization rate (low risk: 45.73%; middle risk: 43.52%, high risk: 33.38%, p<0.001). For functional smart home, smart washing machine (low risk: 37.66%, middle risk: 35.11%, high risk: 26.49%; p<0.001) and smart air conditioner (low risk: 35.95%, middle risk: 29.13%, high risk: 24.61%) were higher than other of this category. For health smart home, sports bracelet has the highest utilization rate (low risk: 37.29%, middle risk: 24.49%, high risk: 22.83%).ConclusionHealth-related risks are an important factor affecting the use of smart homes. Joint efforts of government and product manufacturers are needed to broaden the smart home market and promote the implementation of digital health strategies.