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In view of the problem of power quality degradation of port distribution network after the large-scale application of shore power load, a method of power quality management of port distribution network is proposed. Based on the objective function of the best power quality management effect and the smallest investment cost of the management device, the optimization model of power quality management in the distribution network after the large-scale application of large-capacity shore power is constructed. Based on the balance between the economic demand of distribution network resources optimization and power quality management capability, the power quality of distribution network is considered comprehensively. The proposed optimization algorithm for power quality management based on Matlab and OpenDSS is proposed and analyzed for port distribution networks. The simulation results show that the proposed optimization method can maximize the power quality management capability of the port distribution network, and the proposed optimization algorithm has good convergence and global optimization finding capability.

Clinical observations suggest that identifying novel curative and preventive approaches by targeting the tumor cells without affecting the normal cells is appreciable. Diosgenin (DG) is a natural sapogenin that has been reported of having pro-apoptotic and anti-cancer properties against various neoplasia. Hence, the present study investigated the effect of combined DG/TNF-related apoptosis-inducing ligand (TRAIL) on gastric cancer cell lines (BGC-823) in vitro. Cell viability and IC 50 for DG and TRAIL alone or in combination were determined using MTT. The apoptosis rate was assessed by ELISA cell death assay and Caspase 8 activity assays. The gene expression evaluation of candidate genes, including survivin, Bcl-2, XIAP, c-IAP1, c-IAP2, and c-FLIP, were accomplished before and after the treatment by quantitative real-time PCR. Our results demonstrated that DG synergistically enhanced the cytotoxic effects of TRAIL (p < 0.01). DG could exaggerate cell apoptosis through TRAIL-induced apoptosis and amplify the Caspase 8 activity. These results were confirmed by decreasing anti-apoptotic genes' expression levels. Overall, our findings shed light on a novel strategy of TRAIL-induced apoptosis in combination with DG for the treatment of gastric cancer.

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