The operation of a thermonuclear reactor on an alternative to D-T fuel (D-D, Cat-DD, D-3He, p-11B, p-6Li) requires a higher temperature of the fuel mixture and an increased plasma energy confinement time. It is shown that at a fixed power of thermonuclear reaction, an increase in the peaking of plasma parameters leads to a decrease in power, which is necessary to its addition heating. Moreover, the peaking of the plasma parameters leads to decrease of its radiation losses. All this reduces the requirements for the operating conditions of thermonuclear reactor. Keywords: thermonuclear reactor, alternative fuel, picking.