The use of multiple tissue expanders for GCMN is a safe technique that reduces the number of surgical interventions, achieving a total excision of the nevus in less time and at a younger age. The esthetic results are similar, and we have not observed a higher rate of complications.

Aim of the StudyEndocrine disrupting chemicals (EDC) are exogenous agents that are capable of altering the endocrine system functions, including the regulation of developmental processes. The aim of this study was to investigate the association between endocrine disrupting chemicals (EDC) exposure and other parental factors in the aetiology of hypospadias and cryptorchidism. MethodsA case-control study was conducted. Cases ( 210) were infants between 6 months and 14 years of age diagnosed with hypospadias or cryptorchidism attended in our hospital over a period of 18 months, and controls (210), infants within the same range of age and without any urological disorders who attended the outpatient clinic of the same hospital during the same. Their selection was independent of exposures. Data on parental occupational exposure to EDC and other sociodemographic variables were collected by face-to-face interviews and systematically for both cases and controls. Crude and adjusted odds ratios (OR) were estimated to control for confounding with their 95% CI by means of logistic regressions. Specifically, three final models of dichotomous outcome were constructed: one for cryptorchidism, one for hypospadias, and the third considering both malformations together. Hosmer-Lemeshow test was used to assess the goodness-of-fit of the models. Their discriminatory accuracy (DA) was ascertained by estimating their areas under the receiver-operating-characteristics (ROC) curves (AUC) along with their 95%CI. ResultsAssociations were found between advanced maternal age (OR adjusted=1,82; 95%CI: 1,14-2,92), mother´s consumption of antiabortives (OR=5.40; 1.40-38.5) and other drugs (OR=2.02;

Presentación de casos clínicos RESUMENLos schwannomas son tumores que se originan de las células de Schwann de los nervios periféricos. Su localización en el colon es extremadamente rara y no se han descrito, en la literatura, casos en niños. Por lo general, estos tumores son asintomáticos, pero pueden producir síntomas inespecíficos y gastrointestinales. La presentación como invaginación intestinal es muy infrecuente. Se expone el caso clínico de una paciente de 11 años de edad con un schwannoma de colon manifestado clínicamente como invaginación intestinal de sigma con dolor abdominal, rectorragia y estreñimiento de 10 días de evolución, que precisó resección intestinal con márgenes quirúrgicos libres, con buena evolución posoperatoria. ABSTRACTSchwannomas are tumours originating in the Schwann cells of the peripheral nerves. The appearance in the colon is extremely rare, and there are no known cases in the literature of schwannomas of the colon and rectum described in children. These tumours are usually asymptomatic, but can produce non-specific and gastrointestinal symptoms. The clinical presentation as intestinal intussusception is infrequent. We present a case of an 11-year-old girl with sigmoid swchannoma presented clinically as a colonic intussusception with abdominal pain, rectal bleeding and constipation of 10 days. An intestinal resection with free surgical margins was performed. et al. Invaginación sigmoidea como presentación clínica de schwannoma de colon. Caso pediátrico. Arch Argent Pediatr 2019;117(1):e68-e71.

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