The microelement profile and structure of lymph nodes were studied in experiment using old Wistar rats by means of a morphological method and the X-ray fluorescent analysis with synchrotron radiation. Their special qualitative and quantitative status is formed in regional lymph nodes that reflect age-related dynamics of lymphoid tissue. The content of trace elements and the size of compartments differ in lymph nodes of different localization. Age-related modifications in a microelement profile are characterized by proliferation of lymphoid cells, development of compartments and initiation of a corresponding immune response at the level of regional lymph nodes with different contact to external environment. Localization of lymph nodes is one of conditions for realization of the principle of a regional determinant (regional specifics).

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