The aim: The study was aimed to compare the efficiency of intrathyroid steroid injection to oral steroid intake in patients with subacute thyroiditis. Materials and methods: 32 patients with subacute thyroiditis with insufficient result from NSAIDs treatment were randomly divided into two groups. The 1st group received two intrathyroid steroid injections, the 2nd group received oral prednisone. The results of the treatment were evaluated via ultrasound and evaluation of ESR and CRP at 0, 2, 4, 8 and 16 weeks of treatment. Results: Patients of the 1st group showed much faster result at the ultrasound compared to the 2nd group: mean decrease in hypoechogenity area 44,42% vs 16,35% at week 2, p < 0,001; 93,29% vs 75,98% at week 4, p < 0,001; 97,8% vs 95,24% at week 8, p = 0,4; mean decrease in ESR 66,34% vs 51,92% at week 2, p = 0,023; 84,43% vs 74,94% at week 4, p = 0,023; mean decrease in CRP 26,53% vs 20,77% at week 2, p = 0,024, 33,77% vs 29,98%, at week 4, p = 0,026. No side effects were noted during the treatment of patients of the 1st group. Conclusions: Compared to oral steroid intake intrathyroid steroid injection is faster, safer and generally better tolerated by patients.

Introduction. Superficial vein thrombosis is characterized by the formation of thrombi in the superficial veins with subocclusion or occlusion of the venous lumen and its inflammatory reaction, which occurs more often in the lower extremities. Chronic venous disease in 75–88% of cases is the most important clinically identified factor in the development of superficial vein thrombosis. The great saphenous vein is affected in 60–80% of cases. A population-based study found that the chronic venous disease is a risk factor for venous thromboembolism and correlates with an increased risk of mortality in patients. Venous thromboembolism is a major burden of the disease worldwide, with approximately 10 000 000 cases per year. Objective: to assess the prevalence of superficial vein thrombosis in patients with chronic venous disease and to identify the relationship between the diameter of the great saphenous vein and superficial vein thrombosis. Materials and methods. Total of 925 chronic venous disease cases were analyzed from January 2019 to December 2021 at the Clinical Department of Surgery, Traumatology, Orthopedics, and Phthisiology of Sumy State University (Sumy Laser Clinic, LLC) for the prevalence of superficial vein thrombosis in patients with chronic venous disease who were undergoing treatment. The patients with superficial vein thrombosis were examined for the diameters of great saphenous vein and venous reflux using ultrasound 10 mm below the sapheno-femoral junction, in the upper and lower thirds of the thigh. Results: Of 925 chronic venous disease cases, superficial vein thrombosis was observed in 53 cases, which accounted for 5.73 % of the total. Women accounted for 67.9 % (36), men – for 32.1 % (17). The study included patients aged 25 to 69 years (mean age 52.62 ± 10.48 years). In 69.8 % (37) of superficial vein thrombosis cases, the diameter of great saphenous vein was ≥ 10 mm at a level 10 mm below the sapheno-femoral junction; in 49 % (26) of cases – in the upper third of the thigh; in 30.2 % (16) of cases – in the lower third of the thigh. That is, the extension of the sapheno-femoral junction trunk to the lower third of the thigh was preserved in 43.24% of cases. Conclusion. The results of the study revealed a high prevalence (5.73%) of superficial vein thrombosis. 69.8% of all cases of superficial vein thrombosis was registered in patients with a large diameter (≥ 10 mm) of great saphenous vein.

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The study of comorbid pathologies that influence the severity of the disease and impair the effectiveness of treatment is carried out to optimize the treatment of the main disease. Materials and methods. The total of 132 medical students was divided into two groups: the 1st group: 56 students who didn`t have acne elements, the 2nd group: 76 students with mild acne vulgaris. At the baseline and after 12 months epithelial tape-test was performed to define Demodex mites presence. The theory of chances was used to assess the impact of acne on the occurrence of Demodex mites. Results. The presence of Demodex mites was observed in 3.57% of students in the 1st group and in 21.05% of students in the 2nd group on repeated tape-test. The probability value (P) among students of the 1st group was P1 = 0.037; among students of the 2nd group – P2 = 0.266. The odds (O) indicator in the 1st group of students without acne elements was O1 = 0.04, in the 2nd group diagnosed with acne – O2 = 0.21. The odds ratio (OR) value in the case/control groups was 7.20. Confidence intervals (95% CI) – (1.582, 32.765): the lower limit of the confidence interval (2.019, + ∞); the upper limit of the confidence interval (-∞, 25680). The significance test p-value was 0.00533. Conclusion. Acne vulgaris is one of the aggravating factor that increases the risk of Demodex mites.

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