Interstitial lung disease (ILD) is a large group of diseases with a severe course and, as a rule, an unfavorable prognosis, since irreversible pulmonary fibrosis forms in the outcome of most ILD. Among ILD in children and adolescents, hypersensitivity pneumonitis (HP) is of significant clinical importance. The clinical observation presented in the article demonstrates the first successful experience in our country (2018) of transplanting both lungs to an adolescent with pulmonary fibrosis resulting from the HP chronic course. Lung transplantation has become the only way to prolong the patient's life.

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The importance in a pathogenesis of the wheezing and a development of a nonspecific bronchial hyperreactivity belongs to neurogenic mechanisms. It is known that perinatal damage of the central nervous system are an adverse background for a forwardness of acute wheezing and bronchial asthma at children. The available data on a role of a functional condition of autonomic nervous system at the wheezing aren't numerous and rather contradictory that demands further researches, including in respect of a choice of methods of the rehabilitation. The aim of our study was to determine of the clinical and functional efficiency of including of midget doses of the affine cleared antibodies to S-100 protein in complex rehabilitation of the children of early age with wheezing, depending on the presence of mild severity of perinatal damage to the CNS hypoxic genesis. Our data showed that additional including of midget doses of the affine cleared antibodies to S-100 protein in a complex of rehabilitation of these patients a positive effect on the autonomic imbalance, vegetative component of the wheezing. At the same time, prescription by a short course (less 5 weeks) of midget doses of the affine cleared antibodies to S-100 protein didn't prevent emergence of episodes of the wheezing. Perhaps, patients with recurrent wheezing with the expressed functional disturbances of the autonomic nervous system, need longer courses of the this medicine that can be useful in a complex of rehabilitation.

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