Acute diarrhea (AD) has a complex etiology and may lead to life-threatening conditions. Hematological and serum biochemistry analyses can be useful for a differential diagnosis and for determining the severity of diarrhoea. Dogs with AD (n=72) were divided into Isospora (n=18), Toxocara (n=18), Parvoviral Enteritis (n=18), and Dietary Diarrhea (n=18) subgroups following clinical and laboratory examinations. The study aimed to evaluate the diagnostic value of certain hematological and serum biochemistry parameters. Clinical examinations, rapid diagnostic tests, complete blood count (CBC), and biochemical analyses were performed. White blood cell count (WBC), granulocyte, and mean hemoglobin concentration (MCH) levels were lower in the Parvoviral Enteritis Group compared with the other groups (p<0.01). Isospora, Parvoviral Enteritis, and Toxocara groups had lower glucose and total protein, and higher creatinine levels than those of the Control and Dietary Diarrhea groups (p<0.0001). The albumin level of the Dietary Diarrhea Group was higher compared with the other groups (p<0.0001). Parvoviral Enteritis and Isospora groups had higher ALP levels than those of the other groups (p<0.0001). Blood urea nitrogen (BUN), alanine aminotransferase (ALT), C-reactive protein (CRP), and cholesterol levels were determined to be highest in the Parvoviral Enteritis Group (p<0.0001). The total bilirubin level was higher in Parvoviral Enteritis and Toxocara groups compared with the Control, Isospora, and Dietary Diarrhea groups (p<0.0001). As a result, it was concluded that in cases of AD due to parvoviral enteritis and Toxocara canis, serum biochemistry abnormalities may be more severe, can provide more clinical information than CBC, and can be useful in forming a differential diagnosis list, especially in triage.

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Feline coronavirus (FCoV) infections occur commonly in cats, with entrocyte and monocyte-macrophage tropism. Most FCoV-infected cats remain asymp tomatic, but up to 10% develop fatal feline infectious peritonitis (FIP). This study aims to investigate the diagnostic utility of clinical and laboratory examinations including serum and effusion AGP levels in cats either with symptomatic effusive FIP or asymptomatic feline enteric coronavirus (FECV). The study included 40 cats with effusive FIP and 10 cats with FECV infection. The FIP group was divided into two subgroups: abdominal (AE; n=30) and thoracic effusion (TE; n=10). Clinical and laboratory examinations, including serum or effusion AGP measurement, were performed. Among all the groups, TE group had higher body temperature, heart and respiratory rates (P<0.000). Compared with the FECV group, the FIP group had lower pH and HCO3 levels and higher base excess and lactate levels (P<0.05). The leukocyte and lymphocyte counts were higher and the hematocrit was lower in the AE group among all the groups (P<0.023). MCV was lower in the FIP group compared to the FECV group (P<0.002). In the AE group, total protein level was the lowest and the AST, GGT, total bilirubin and cholesterol levels were the highest (P<0.032) among all the groups. Magnesium level was lower in the FIP group compared to the FECV group (P<0.044). Although the serum AGP level was highest in the TE group among all groups (P<0.004), the AGP levels of cats with FECV were similar to the AE group (P>0.05). Since FECV-positive cats will likely develop FIP, differences in clinical and laboratory findings in FECV-positive cats were identified. Among them, pH, HCO3, base excess, lactate, MCV and magnesium were found to be important in the course of the disease, and AGP in the evaluation of the presence of an inflammatory state. It was concluded that clinical, laboratory and serum AGP evaluation could be used in the index of suspicion of development of FIP and FECV.