Aim: The study aimed at comparing the effects of ethanolic extract of Sesamum indicum seeds with mesterolone on some testicular morphometry following ketoconazole induced damage in Wistar rats. . Methods: Thirty-six (36) adult male Wistar rats were divided into six (6) groups of six rats each. Groups 1,2,3,4,5 and 6 were administered 1 ml of normal saline, 100 mg /kg body weight (bwt) of Ketoconazole only, 500 mg/kg bwt of Ethanolic Extract of Sesamum indicum (EESI) seeds then 100 mg/kg bwt of Ketoconazole,100 mg/kg bwt of Ketoconazole then 250 mg /kg body weight of EESI seeds,100 mg/kg bwt of Ketoconazole then 500 mg/kg bwt of EESI, 100 mg/kg body weight of Ketoconazole, respectively. All administrations were carried out orally and once per day. The histological slides were prepared for morphometric analyses. Results: No observed significant differences in the morphometry of the groups administered EESI and Mesterolone. However, the morphometry of the group administered EESIS and Mesterolone were significantly increased when compared with group 2 alone (P ≤ 0.05). Conclusions: The effects of the administration of ethanolic extract of Sesamum indicum seeds on the morphometry of the testis appeared to be indifferent with Mesterolone; and both EESIS. Mesterolone also appeared to have minimize the distortion of the normal dimensions of the testis caused by ketoconazole which may be due to their androgenic properties.

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Aim: The study was aimed at evaluating the effects of ethanolic extract of Sesamum indicum seeds on sperm morphology and viability in ketoconazole induced testicular damage in Wistar rats. Methods: Forty eight adult male Wistar rats were divided into eight Groups of six rats each. Groups 1,2,3,4,5,6,7 and 8 were administered 1ml of normal saline, 100 mg /kg body weight (bwt) of Ketoconazole only, 500 mg/kg bwt of ethanolic extract of sesamum indicum (EESI) seeds then100 mg/kg bwt of Ketoconazole, 100 mg/kg bwt of Ketoconazole then 250 mg /kg body weight of EESI seeds,100 mg/kg bwt of Ketoconazole then 500 mg/kg bwt of EESI, 100 mg/kg body weight of Ketoconazole then 0.36 mg/kg body weight of Mesterolone, 0.36 mg/kg body weight of Mesterolone, 500 mg/kg body weight of EESI respectively. All administrations were carried out orally once per day. The sperm smears were collected for semen analyses. Result: A significant increase in the abnormalities of sperm morphology and viability respectively were noted in the group administered ketoconazole alone (Group 2) compared with other experimental Groups (P ≤ 0.05). Conclusions: The administration of ethanolic extract of Sesamum indicum appeared to have minimized the damages and sperm deaths caused by ketoconazole which may be due to its androgenic properties.