Narkolepsi çekirdek semptomlar olarak karşı konulmaz gündüz uykululuk hali, katapleksi, bunlara eşlik eden hipnogojik/ hipopompik halüsinasyonlar ve uyku paralizisi ile karakterize santral hipersomnolans grubunda yer alan nörolojik bir hastalıktır (1). Uyku ataklarının en önemli özelliği, hastanın günlük işleri sırasında aniden ortaya çıkması, 10-20 dakika kadar sürmesi, uykunun dinlendirici karakterde olması fakat atağı takip eden 2-3 saat içinde hastanın tekrar karşı konulamaz uyku isteği duymasıdır. Narkolepsi için güncel sınıflama değişmiş olup artık katapleksili ve katapleksisiz narkolepsi yerine tip 1 ve tip 2 narkolepsi şeklinde sınıflandırılması önerilmektedir (2). Amerika Birleşik Devletleri kaynaklı çalışmalarda narkolepsinin uyku apne sendromu ve huzursuz bacaklar sendromundan sonra üçüncü sırada en sık görülen uyku bozukluğu olduğu ortaya konulmuştur (3). Ülkeler ve etnik gruplar arasında farklılık gösterse de narkolepsi prevalansı %0,03 ile %0,1 oranları arasında değiştiği bildirilmektedir. Erken çocukluk ve beşinci dekadda yaşlarda Narcolepsy is neurological disorder classified among central hypersomnolences group and characterized by excessive daytime sleepiness, cataplexy, associated symptoms like hypnogogic/ hypnopompic hallucinations and sleep paralysis. It is divided into two types on the basis of accompanying cataplexy. In the pathophysiology of this disorder, which is accused an autoimmune process, hypocretin deficiency in the hypothalamus was shown. Narcolepsy is often seen as a primary disease in young population but may also occur with other disorders like cerebrovascular diseases, intracranial tumors, encephalitis, sarcoidosis, multiple sclerosis or after head trauma, infections, and vaccines; in which the disease is accepted as secondary narcolepsy. In this case report, patients presenting with excessive daytime sleepiness and diagnosed as having secondary narcolepsy due to medical causes, and who have Parkinson's disease (PD), history of interferon use and hypothalamic involvement associated with Langerhans cell histiocytosis (LCH) were reported. Daytime sleepiness complaints should be well questioned in organic pathologies related with hypothalamus-pituitary system such as PD and similar diseases or in patients with history of drug use and secondary narcolepsy should be beared in mind.
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