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This study aims to evaluate the safety and efficacy of a poly lactic-co-glycolic acid (PLGA)-coated β-tricalcium phosphate (β-TCP) with N-methyl-2-pyrrolidone (NMP) liquid activator (PLGA/β-TCP) on alveolar ridge preservation after tooth extraction in dog mandible. Thirty-two extraction sites were prepared in eight dog mandibles. A distal root of the mandibular premolar was extracted and randomly grafted with one of the following bone substitutes: (1) PLGA/β-TCP, (2) β-TCP, or (3) left empty as a control, and wounds were closed with keratinized mucosa graft. Post-operative wound healing was observed and scored to evaluate safety. After 12 and 24 weeks, the bone regeneration was evaluated with micro-computed tomography (CT) images and histomorphometric analyses. Gingival epithelization progressed over time without complication or infection. Micro-CT images and histological observation revealed that both PLGA/β-TCP and β-TCP granules supported sufficient new bone formation. Although bone formation and substrate resorption were delayed slightly with the PLGA and the NMP-containing plasticizer as compared to those treated with conventional β-TCP, it can be concluded that the PLGA and the NMP-containing plasticizer that facilitated the in situ hardening properties of the material had no negative influence on the biocompatibility of the material.

This paper studies linear-time-invariant (LTI) modeling of a twin-rotor MIMO system based on the dynamical models derived from the first principles and identification experiments, motivated by building LPV (Linear Parameter Varying) models. The present method proposes using the states of the first-principle-model and the identification-model. Continuous-time local LTI models with a consistent state are obtained in the frequency domain. It is also shown that an LPV model is computed from the local models.

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<div class="section abstract"><div class="htmlview paragraph">The power train system for Utility Vehicles (UVs) or All-Terrain Vehicles (ATVs) mainly consists of a rubber V-belt CVT. The adjustment of the CVT specification requires many steps to realize the shifting operations of the CVT so as to satisfy the acceleration feeling of the driver.</div><div class="htmlview paragraph">In this paper, we report on the simulation technology that predicts the transient behavior during an acceleration of the vehicle equipped with a belt tension clutching CVT, which has both functions of the shift operation and the clutch action. By using the developed simulation technique, it has become possible to adjust the CVT specifications efficiently.</div></div>