The combined use of chiral Pd complex 2 and amine salt enabled completely regulated release of free nucleophilic amine. Under these conditions, an efficient catalytic asymmetric conjugate addition of various amines was achieved to afford beta-amino acid derivatives in high chemical yields with up to 98% ee. Furthermore, a highly enantioselective protonation in 1,4-addition of amine was also developed. [reaction: see text]

No abstract

No abstract

Indole derivatives R 0140Catalytic Enantioselective Fluorination of Oxindoles. -An efficient enantioselective fluorination of oxindoles is developed. The reactions are operationally convenient and can be performed without exclusion of air and moisture. Application of the enantioselective fluorination to (V) affords oxindole (VI) which is converted into optically pure BMS 204352 (MaxiPost) (VII). -(HAMASHIMA, Y.; SUZUKI, T.; TAKANO, H.; SHIMURA, Y.; SODEOKA*, M.; J. Am. Chem. Soc. 127 (2005) 29, 10164-10165; Inst. Multidiscip. Res. Adv. Mater., Tohoku Univ., Sendai 980, Japan; Eng.) -Bartels 46-110