An effective method for the total synthesis of 1 (AMF-26), a potentially promising new anticancer drug that disrupts the Golgi system by inhibiting the ADP-ribosylation factor 1 (Arf1) activation, has been developed for the first time. The construction of the chiral linear precursor (a key to the synthesis) was achieved by the asymmetric aldol reaction followed by the computer-assisted predictive stereoselective intramolecular Diels-Alder reaction. The global antitumor activity of the totally synthetic 1 against a variety of human cancer cells was assessed using a panel of 39 human cancer cell lines (JFCR39), and it was shown that the synthetic 1 strongly inhibited the growth of several cancer cell lines at concentrations of less than 0.04 μM. Biological assays of novel derivatives, 26 and 31, which have different side-chains at the C-4 positions in the Δ¹,²-octalin backbone, disclosed the importance of the suitable structure of the side-chain containing conjugated multidouble bonds.

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Soft hydrogel, which contains a amount of water and also has a unique touch feeling, will be required for practical applications around soft-matter robotics including the medical field because it has an unique softness that is close to the living body and has a biocompatibility. Among them, our SWEL developed RepRap SWIM-ER, a desktop type 3D gel printer that enables 3D free-formation of soft hydrogels. The RepRap SWIM-ER is a device that can shape the soft hydrogels into a desired shape by moving a laser pointer as the light source and irradiating the gel solution in the bathtub with ultraviolet light for photo-induced gelation. This 3D gel printer can be realized at low cost because it utilizes the results of the RepRap open source project to design the device and control it with software. Furukawa established the “Soft 3D Co-creation Consortium” (URL: https://soft3d-c.jp) in April 2018. Considering the members of this consortium as test users, we will provide a desktop type 3D gel printer RepRap SWIM-ER. First, in the field of research and development, we will use the 3D printing of soft hydrogel materials and share the practical use cases among the consortium members At the same time, we are planning to standardize the several methods concerning both the material design of 3D gel printers and the evaluation of shaped objects. Figure 1

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