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An electrochemical technique for preparation of a molecularly imprinted overoxidized polypyrrole (oPPy) film and its recognition property for bile acids are investigated, aiming for application to a bile acid sensor and clarification of the principle of the recognition mechanism with the quartz crystal microbalance. The molecularly imprinted oPPy has been prepared through a potentiodynamical overoxidation process in an alkaline solution from a taurocholate (TC) doped polypyrrole (PPy) film grown on an Au electrode. The molecularly imprinted film exhibited a high selectivity and sensitivity toward bile acids. Cholate, chenodeoxycholate, deoxycholate, TC, and artificially synthesized dehydrocholate showed a linear relationship between the resonance frequency and their logarithmic concentrations in a range from 10−9to10−5M with detection limits for trace concentrations (∼25nM) . The sensitivity of an oPPy film imprinted with TC increased in the sequence of TC (28.80.3emHz∕log0.3emconcentration)

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