Pancreatitis is one of the most frequent gastrointestinal tract disease for hospitalization all over the world, leading to tremendous emotional, physical and financial human burden. The spectrum of aetiological factors for pancreatitis varies according to continents. Hyperlipidaemia is a rare but known and established risk factor for pancreatitis and goes undetected in most of the clinical settings. Early diagnosis of hyperlipidaemia induced pancreatitis is important to prevent its recurrence and complications. METHODThis is a prospective study carried out on patients with pancreatitis over a period of two years in M.K.C.G. Medical College and Hospital, Berhampur, Odisha, India. Fifty cases of pancreatitis of different age group and both sexes were selected. Equal number of age and sex matched patients other than pancreatitis were taken as control from the indoor. The mean serum lipid profiles of cases were compared with the control group. RESULTIn this study it was observed that the Serum Total Cholesterol, Triglycerides, Low Density Lipoprotein and Very Low Density Lipoprotein were significantly higher in cases than controls, while HDL was found to be higher in controls. Young males were commonly affected and alcohol abuse is the most common risk factor followed by biliary stones. CONCLUSIONAll pancreatitis patients should be evaluated for any alteration in their serum lipid profile, if found to be treated with antilipidaemic drugs, dietary modulation, lifestyle change and physical exercise to limit the occurrence of this disease, pre vent its complications and to control the possibility of future recurrences.

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INTRODUCTION : Thyroid cancer is one of the most common endocrine cancer and has the highest mortality among endocrine neoplasms. In India, its incidence is between 0.8–2 per 1,00,000 population. Early diagnosis and treatment remain the cornerstone of management to decrease the mortality rates. lack of prospective randomized trials, the management of these cancers generates tremendous controversy. study was planned to assess & evaluate the management of various thyroid carcinomas. METHODS: A total of 40 patients were selected which were pathologically / histologically proven cases of Thyroid carcinoma in this Prospective study design in 2.5 years. Detailed Clinical Examination was done & Prior to surgery all the patients went through investigations. Subjects included both the genders , all age groups including pediatric and geriatric age group and all classes of socio economic strata. RESULTS: No of female patients were 30 and male patients 10.Male :female ratio in this study was 1:3.FNAC / Biopsy / Cytology detected papillary carcinoma in 26 patients (65%) ,follicular neoplasm in 11 patients (27.5%) ,2 (5%) patients of anaplastic and one (2.5%) of medullary carcinoma. 86.6% of the patients had a firm gland & hard gland and rest presented with a soft gland on palpation.Total Thyroidectomy with cervical block dissection was performed in 32 (80%) cases .Rest of the 20 % were dealt with Sub total Thyroidectomy with cervical block dissection. CONCLUSION: Most of the cancers present as a slow growing goiter for few months to few years duration.Most of the cancers are of papillary carcinoma type , FNAC detects the majority of the cancers and is an important diagnostic test.Thyroid cancers have a good prognosis as most of the patients present as Stage I disease & most of the patients require total thyroidectomy with or without lymph node dissection followed by radio iodine ablation as treatment.Thyroid cancer,irrespective of the extent of disease,has good prognosis

ABSTRACT:Gastrointestinal perforation is one of the common surgical emergency worldwide and its spectrum is different in India from its western counterpart. With the advancement of medical science still the morbidity and mortality rate is not acceptable. The data regarding the factor affecting the morbidity and mortality is still unclear in India. The present study is conducted in M.K.C.G. Medical College Brahmapur, Odisha in the Dept. of Gen. Surgery on 30 patients with intraoperative findings of gastroduodenal perforation presented to the surgical OPD between July 2014 to Nov 2014 and post op follow up was done till the discharge of the patient from the hospital. OBJECTIVES: To highlight the common cause of gastroduodenal perforation, age/sex commonly affected and the factor that influence the morbidity and mortality related to it. RESULTS: In our study the most common cause of gastroduodenal perforation is chronic and heavy alcohol intake followed by NSAID intake, common age group and sex with predisposing factor is 50 -59yrs. males (36.6%). Morbidity and mortality is higher in elderly patients (>60 yrs.) with late presentation to health care center, poor general condition of patient and their pre -operative co-morbid condition. Most common entity is D1 Anterior wall perforation. CONCLUSION: The two common cause of gastroduodenal perforation in our study is chronic and heavy alcohol intake followed by NSAID intake and it is preventable. Late presentation to the hospital still remains an important factor for increase in morbidity and mortality for patient of perforation peritonitis. We need to develop a system for early diagnosis and early referral to tertiary care and make the community aware about the risk factor to decrease the morbidity and mortality due to this disease.