Effective pH-responsive anticancer drug nanocarriers can be simply prepared through post-polymerization modification of a single pentafluorophenyl ester-containing polymer.
An enzyme-immobilized platform for biocatalysis was developed
through
3D printing of a hydrogel ink comprising dimethacrylate-functionalized
Pluronic F127 (F127-DMA) and sodium alginate (Alg) with laccase that
can be done at ambient temperature, followed by UV-induced cross-linking.
Laccase is an enzyme that can degrade azo dyes and various toxic organic
pollutants. The fiber diameter, pore distance, and surface-to-volume
ratio of the laccase-immobilized and 3D-printed hydrogel constructs
were varied to determine their effects on the catalytic activity of
the immobilized enzyme. Among the three geometrical designs investigated,
the 3D-printed hydrogel constructs with flower-like geometry exhibited
better catalytic performance than those with cubic and cylindrical
geometries. Once tested against Orange II degradation in a flow-based
format, they can be reused for up to four cycles. This research demonstrates
that the developed hydrogel ink can be used to fabricate other enzyme-based
catalytic platforms that can potentially increase their industrial
usage in the future.
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