This study establishes normal values for anorectal pressure by 3D-HRM in asymptomatic volunteers. There are significant gender differences concerning squeeze patterns. Increasing age is associated with lower maximum resting pressure, mean resting pressure, and maximum squeeze pressure. Normal characteristic pressure morphology of anorectum can be obtained at rest, during squeeze, and bear down as in defecation by 3D-HRM.

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An urban transit system can be made more cost-efficient by improving the access to it. Efforts in this vein often entail the provision of greater mobility, as when highspeed feeder buses are used to carry commuters to and from trunk-line stations. Other efforts have focused on the creation of more favorable land-use patterns, as occurs when households within a Transit-Oriented Development (TOD) are tightly clustered around trunk stations. The efficacy of these mobility and land-use solutions are separately examined in the present work. To this end, continuum approximation models are used to design idealized transit systems that minimize the generalized costs to both the users and the operators of those systems.The assessments unveil how the choice of rolling-stock for the trunk-line portion of a transit network can be influenced by its access mode. If transit is accessed solely (and slowly) on foot, then the optimal spacings between lines, and between the stations along those lines, are small. This can place capital-intensive rail systems at a competitive disadvantage with transit systems that feature buses instead. When access speeds increase, the optimal spacings between lines and stops expand as well. Hence, if accessed by fast-moving feeder buses, Metro-rail or bus-rapid transit can become preferred trunk-line options.By comparison, the influence of altered land use patterns brought by TODs was found to be less dramatic. While clustering households around Metro-rail stations justifies larger spacings between the stations, it yields only modest reductions in generalized costs because the larger spacings penalize transit users who reside outside of the TODs.

The maximal rates that buses can discharge from bus stops are examined. Models were developed to estimate these capacities for curbside stops that are isolated from the effects of traffic signals. The estimates account for key features of the stops, including their target service levels assigned to them by a transit agency. Among other things, the models predict that adding bus berths to a stop can sometimes return disproportionally high gains in capacity. This and other of our findings are at odds with information furnished in professional handbooks.

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