Background: The 3D-print technology has been widely used in the medical field. The purpose of this study is to investigate the advantages of 3D-print model pre-operation for percutaneous kyphoplasty (PKP).Methods: Before the operations of 25 Osteoporotic vertebral body compression fractures (OVCF) cases as the experimental group, and 35 cases of the same disease in the same period were retrospectively selected as the control group without pre-operation. The 3D-print model was made by CT imagine. The puncture point and insertion angle were determined by the pre-operation on that model. The data recorded included data about operation time/fluoroscopy times/Changing channel times and preoperative and postoperative VAS(Visual Analogue Score), JOA(Japanese Orthopedic Association) score, Cobb’s angles.Results: There are significant advantages in the 3D printing group compared with the control group in the time of operation, the number of tunnel changes and the number of perspectives (p<0.05). The postoperative Cobbs angle is significantly improved (p<0.05) in both the short and long term compared with the control group. The recent postoperative VAS score is significantly lower than that in the control group (p<0.05), and there is no significant difference in the long-term postoperative VAS score. There is no significant difference between the two groups of JOA functional score and improvement index.Conclusions: preoperation with 3D-print model can significantly improve the accuracy, reduce the change times of tunnels, shorten the operation time and reduce the number of fluoroscopy. Postoperative pain can be better relieved.