No abstract

Through the self‐condensation of α‐amino aldehydes, the synthesis of symmetrical disubstituted pyrazines was achieved in a three‐step one‐pot reaction. The α‐amino aldehydes were easily obtained by treating methyl esters of natural α‐amino acids with diisobutylaluminium hydride.

An original approach for the synthesis from PGA2 of C-10 substituted PGE2 analogues is reported. A remarkable regio- and cyclo-selective Baeyer–Villiger reaction is described.

A New Method for the Synthesis of Symmetrical Disubstituted Pyrazines. -Self-condensation of α-amino aldehydes, obtained in situ by reduction of α-amino methyl esters (I), leads to pyrazines (II) in a three-step, one-pot reaction. -(ROJAS, N.; GRILLASCA, Y.; ACOSTA, A.; AUDELO, I.; GARCIA DE LA MORA*, G.; J. Heterocycl. Chem. 50 (2013) 4, 982-984, http://dx.

Mesityloxid ergibt mit Lithiumdiisopropylamid in Tetrahydrofuran bei ‐78°C das kinetische Enolat (I), das mit (II) zu α‐Bisabololone (III) reagiert.