Findings: Out of the 65 patients recruited for the study, 28 (43.1%) had anemia, 17 (26.2%) had leukopenia, 6 (9.2%) had leukocytosis, 13 (20%) had thrombocytopenia, and 8 (12.3%) had thrombocytosis. 25 patients (38.5%) had no abnormalities, compared to 38 patients (61.5%) that presented with at least one hematological abnormality. 24 patients (36.9%) patients presented with lower levels of one cell line only. Another 14 patients (21.5%) presented with lower levels of multiple cell lines, and 3 patients (3%) presented with lower levels of all three cell lines (pancytopenia). Hematological abnormalities were the second most common clinical presentation of SLE, second only to arthritis/arthralgia. Interpretation: The majority of patients studied had hematological abnormalities; among these patients, anemia was the most common clinical presentation. Overall, hematological abnormalities were the second most common clinical feature of patients with SLE. Levels of anemia and thrombocytopenia were consistent with what has been demonstrated in Western countries. Comparing these values with similar studies in other African settings may guide future research.