Background: It seems that some herbal medicines such as sage or vitagnus traditionally used as treatment agents are effective on menopausal symptoms such as hot flashes; therefore, the current study aimed at assessing the effect of vitagnus on menopausal symptoms. Methods: The current study was a prospective clinical trial conducted on 100 menopausal patients divided into 3 groups. In each group, hot flash was treated with vitagnus, sage, or placebo pills and patients were followed-up at the days 15 and 30 after the treatment. The data were analyzed by descriptive (percentage, mean, and standard deviation) and inferential (chi-square, t-test, McNamara, repeated ANOVA) statistics with SPSS software, version 21 (IBM SPSS, Armonk, NY, USA).