Background and Purpose Identifying cerebral microhemorrhage (CMH) burden can aid in the diagnosis and management of traumatic brain injury (TBI), stroke, hypertension, and cerebral amyloid angiopathy. MRI susceptibility based methods are more sensitive than CT for detecting CMH, but methods other than quantitative susceptibility mapping (QSM) provide results that vary with field strength and echo times, require additional phase maps to distinguish blood from calcification and depict CMHs as bloom artifacts. QSM provides universal quantification of tissue magnetic property without these constraints, but traditionally requires a mask (mQSM) generated by skull-stripping, which can pose challenges at tissue interphases. We evaluate the preconditioned QSM (pQSM) MRI method, which does not require skull-stripping, for improved depiction of brain parenchyma and pathology. Materials and Methods 56 subjects underwent brain MRI with 3D multi-echo GRE acquisition. MQSM images were created using a commonly used mask based QSM method and pQSM images were made using precondition based total field inversion. All images were reviewed by a neuroradiologist and a radiology resident. Results 10 subjects (18%), all with TBI, demonstrated blood products on 3D GRE. All lesions were visible on pQSM, while 6 were not visible on mQSM. 31 subjects (55%) demonstrated brain parenchyma and/or lesions which were visible on pQSM but not on mQSM. 6 subjects (11%) demonstrated pons artifacts on pQSM and mQSM, worse on pQSM. Conclusion pQSM MRI can bring the benefits of QSM imaging to clinical practice without the limitations of mQSM, especially for evaluating CMH associated pathologies, such as TBI.