Current study aimed to identify the gross and microscopic lesions and their percentage in liver of cattle slaughtered in Kirkuk province abattoir. A total of 6211 liver sample were examined during period from 01/08/2016 until 01/12/2016 with total cattle liver that showed gross lesions 738 cases. A gross examination was applied to affected liver and tissue sample were taken from lesions for histopathological examination. The result of current study showed that the total liver lesions in cattle is about 11.88% (738/6211) which distributed as liver fluke infestation 3.34% (213/6211), hydatid cyst 3.12% (194/6211), liver abscess 2.29% (142/6211), cholangiohepatitis 2.01% (125/6211), and hepatic hemorrhage with congestion 1.03% (64/6211). The results of gross and microscopic examination of liver infested with liver fluke showed presence of thickening in bile ducts