Objectives: The aim of the research was to analyze the impact of selected factors: years of service, the number of interventions, self-efficacy and stress, on occupational burnout. It was hypothesized that firefighters with more years of service and a bigger number of interventions would be characterized by higher perceived stress and burnout, and that self-efficacy would have an impact on reducing the level of perceived stress and burnout. Material and Methods: The participants were firefighters (N = 576) from 12 Polish voivodeships, aged 20-58 years, with different seniority: up to 3, 4-8, 9-15 or >15 years of service. The following research tools were used: the Link Burnout Questionnaire, the 10-item Perceived Stress Scale, the Generalized Self-Efficacy Scale, and an independent questionnaire to gather additional information. A correlation between particular variables was carried out; the Kruskal-Wallis test was performed together with a post-hoc analysis to examine differences in the severity of individual variables depending on seniority, followed by a path analysis studied together with the identification of direct and indirect impacts. Results: The number of interventions did not affect the severity of experienced stress or any of the aspects of burnout. Work experience directly influenced the level of perceived stress (β = 0.219), disillusion (β = 0.076), and relationship deterioration (β = -0.156). The generalized sense of self-efficacy was found to impact both on reducing the sense of stress (β = -0.418) and on all 4 aspects of professional burnout: psychophysical exhaustion (β = -0.181), relationship deterioration (β = -0.16), the sense of professional inefficacy (β = -0.275) and disillusion (β = -0.143). Conclusions: The results have shown that: 1) the number of interventions does not affect the severity of experienced stress or particular aspects of burnout; 2) years of service increase the severity of experienced stress and occupational burnout; 3) self-efficacy has an impact both on reducing the sense of stress and on all aspects of burnout. Int J Occup Med Environ Health. 2020;33(3):283-97

The aim of the study was to investigate the potential role of nitric oxide (NO) on the microcirculation in experimental acute pancreatitis in rats. Twenty-five rats were divided into the following groups: group A (5 rats) = control; group B (5 rats) = acute pancreatitis induced by retrograde taurocholate infusion into the pancreatobiliary duct without treatment; group C (5 rats) = acute pancreatitis treated with the NO donor L -arginine; group D (5 rats) = acute pancreatitis treated with the NO synthase inhibitor N-nitro- L -arginine (L-NNA); group E (5 rats) = without pancreatitis receiving L -NNA. The animals were observed throughout 4 h. The microcirculatory values of the pancreas, liver, colon, stomach and kidney were measured by means of laser Doppler flowmetry. Three animals of group D died after the third hour of the experiment. In rats with pancreatitis, a rapid decrease in microcirculatory values was observed. The most pronounced drop in capillary blood flow within all the organs was observed in rats treated with the NO synthase inhibitor L -NNA, L -arginine administration in rats with acute pancreatitis slightly improved the microcirculatory values, although the improvement was significant in colon perfusion only. We conclude that NO may have a beneficial influence on the capillary organ perfusion in acute pancreatitis. The administration of an NO synthase inhibitor seems to have a detrimental effect on acute pancreatitis.

Patients after alcohol-induced IPN had lower quality of life compared with biliary etiology. Biliary and alcohol-induced IPN patients after surgical treatment have nonsignificant differences of endocrine and exocrine pancreatic functions.

Microcirculatory disturbances of the colon may contribute to the pathogenesis of inflammatory bowel disease. The aim of the study was to investigate the alterations of rectal blood perfusion in experimental colitis with reference to nitric oxide and heparin treatment. The study was carried out on 36 rats, divided into six groups: group I, control; group II, control + NG-nitro-L-arginine (L-NNA); group III, colitis without treatment; group IV, colitis + L-arginine; group V, colitis + L-NNA; group VI, colitis + heparin treatment. Experimental colitis was induced by 4% acetic acid enema, and 48 h after the enema, besides the measurement of rectal capillary blood flow by means of laser Doppler flowmetry, the serum interleukin-6 (IL-6) level and histopathological alterations within the rectal mucosa were examined. Experimental colitis resulted in a drop in rectal wall perfusion. L-Arginine and heparin treatment improved the microcirculatory values. The highest IL-6 level and the most advanced histopathological alterations were observed in the rats treated with L-NNA. L-Arginine treatment had no influence on IL-6 concentration, however it aggravated the inflammatory changes within the rectal mucosa. Heparin administration reduced the IL-6 values and also had a positive impact on the microscopic alterations within the rectal wall. It is concluded that heparin treatment has a beneficial effect on the microcirculatory disturbances and inflammatory changes observed in experimental colitis. The inhibition of nitric oxide-synthase aggravated the course of experimental colitis. L-Arginine administration improves the rectal blood flow but aggravates the histopathological alterations within the rectal wall.

Heparin administration has a positive influence on organ microcirculatory disturbances accompanying experimental Cn-induced acute pancreatitis.