Artificial Neural networks (ANN) are composed of nodes that are joint to each other through weighted connections. Deep learning, as an extension of ANN, is a neural network model, but composed of different categories of layers: input layer, hidden layers, and output layers. Input data is fed into the first (input) layer. But the main process of the neural network models is done within the hidden layers, ranging from a single hidden layer to multiple ones. Depending on the type of model, the structure of the hidden layers is different. Depending on the type of input data, different models are applied. For example, for image data, convolutional neural networks are the most appropriate. On the other hand, for text or sequential and time series data, recurrent neural networks or long short-term memory models are the better choices. This chapter summarizes the state-of-the-art deep learning methods applied to the healthcare industry.

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Nowadays, the confidentiality of data and information is of great importance for many companies and organizations. For this reason, they may prefer not to release exact data, but instead to grant researchers access to approximate data. For example, rather than providing the exact income of their clients, they may only provide researchers with grouped data, that is, the number of clients falling in each of a set of non-overlapping income intervals. The challenge is to estimate the mean and variance structure of the hidden ungrouped data based on the observed grouped data. To tackle this problem, this work considers the exact observed data likelihood and applies the Expectation-Maximization (EM) and Monte-Carlo EM (MCEM) algorithms for cases where the hidden data follow a univariate, bivariate, or multivariate normal distribution. The results are then compared with the case of ignoring the grouping and applying regular maximum likelihood. The well-known Galton data and simulated datasets are used to evaluate the properties of the proposed EM and MCEM algorithms.