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We designed and fabricated a novel catalytic system with high heterogeneity and magnetic features to facilitate the MCR synthetic reactions of 9-phenyl hexahydroacridine pharmaceutical derivatives.

In the present work, a new protocol was introduced for the preparation of an efficient hybrid nanocatalyst ZnS-ZnFe 2 O 4 via the co-precipitation method as well as its application in the synthesis of 2,4,5-triaryl-1H-imidazoles derivatives starting from various aromatic aldehydes, benzil and ammonium acetate under ultrasonic irradiation in ethanol. ZnS-ZnFe 2 O 4 was characterized by Fourier transform infrared (FT-IR) spectroscopy, energy-dispersive X-ray spectroscopy (EDS) analysis, scanning electron microscopy (SEM) image, X-ray diffraction (XRD) pattern and vibrating sample magnetometer (VSM) curve. This method has advantages such as high efficiency of the heterogeneous catalyst, the use of environmentally-friendly solvent, high yields, short reaction times and easy isolation of the products and chromatography-free purification. Our outcomes illustrated that the present nanocatalyst with nearly spherical and Cauliflowerlike morphology and average particle size of 36 nm could be applied as an effective and magnetically recyclable catalyst without any significant decreasing of activity. Furthermore, the synergic effect of bimetallic Lewis acids was studied for the synthesis of imidazole derivatives.

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