Insomnia is a widespread neuropsychological sleep-related disorder known to result in various predicaments including cognitive impairments, emotional distress, negative thoughts, and perceived sleep insufficiency besides affecting the incidence and aggravation of other medical disorders. Despite the available insomnia-related theoretical cognitive models, clinical studies, and related guidelines, an evidence-based conceptual framework for a personalized approach to insomnia seems to be lacking. This study proposes a conceptual cognitive framework (CCF) providing insight into cognitive mechanisms involved in the predisposition, precipitation, and perpetuation of insomnia and consequent cognitive deficits. The current CCF for insomnia relies on evaluative conditional learning and appraisal which generates negative valence (emotional value) and arousal (cognitive value). Even with the limitations of this study, the suggested methodology is well-defined, reproducible, and accessible can help foster future high-quality clinical databases. During clinical insomnia but not the neutral one, negative mood (trait-anxiety) causes cognitive impairments only if mediating with a distorted perception of insomnia (Ind-1 = 0.161, 95% CI 0.040–0.311). Further real-life testing of the CCF is intended to formulate a meticulous, decision-supporting platform for clinical interventions. Furthermore, the suggested methodology is expected to offer a reliable platform for CCF-development in other cognitive impairments and support the causal clinical data models. It may also improve our knowledge of psychological disturbances and complex comorbidities to help design rehabilitation interventions and comprehensive frameworks in line with the “preventive medicine” policies.

The use of transcranial Electrical Stimulation (tES) in the modulation of cognitive brain functions to improve neuropsychiatric conditions has extensively increased over the decades. tES techniques have also raised new challenges associated with study design, stimulation protocol, functional specificity, and dose-response relationship. In this paper, we addressed challenges through the emerging methodology to investigate the dose-response relationship of High Definition-transcranial Direct Current Stimulation (HD tDCS), identifying the role of negative valence in tinnitus perception. In light of the neurofunctional testable framework and tES application, hypotheses were formulated to measure clinical and surrogate endpoints. We posited that conscious pairing adequately pleasant stimuli with tinnitus perception results in correction of the loudness misperception and would be reinforced by concurrent active HD-tDCS on the left Dorsolateral Prefrontal Cortex (dlPFC). The dose-response relationship between HD-tDCS specificity and the loudness perception is also modeled. We conducted a double-blind, randomized crossover pilot study with six recruited tinnitus patients. Accrued data was utilized to design a well-controlled adaptive seamless Bayesian dose-response study. The sample size (n = 47, for 90% power and 95% confidence) and optimum interims were anticipated for adaptive decision-making about efficacy, safety, and single session dose parameters. Furthermore, preliminary pilot study results were sufficient to show a significant difference (90% power, 99% confidence) within the longitudinally detected self-report tinnitus loudness between before and under positive emotion induction. This study demonstrated a research methodology used to improve emotion regulation in tinnitus patients. In the projected method, positive emotion induction is essential for promoting functional targeting under HD-tDCS anatomical specificity to indicate the efficacy and facilitate the dose-finding process. The continuous updating of prior knowledge about efficacy and dose during the exploratory stage adapts the anticipated dose-response model. Consequently, the effective dose range to make superiority neuromodulation in correcting loudness misperception of tinnitus will be redefined. Highly effective dose adapts the study to a standard randomized trial and transforms it into the confirmatory stage in which active HD-tDCS protocol is compared with a sham trial (placebo-like). Establishing the HD-tDCS intervention protocols relying on this novel method provides reliable evidence for regulatory agencies to approve or reject the efficacy and safety. Furthermore, this paper supports a technical report for designing multimodality data-driven complementary investigations in emotion regulation, including EEG-driven neuro markers, Stroop-driven attention biases, and neuroimaging-driven brain network dynamics.

Background: Cancer is one of the most serious chronic diseases and risk factors for population health. Breast cancer is the most common cancer diagnosed in females. Today, some researchers in the field of clinical psychology by the implementation of psychosocial interventions sought to examine these effects on psychopathology in patients with breast cancer. Objectives: The present study aimed to assess the efficacy of mindfulness-based cognitive therapy on the improvement of cognitive emotion regulation and decrease of clinical symptoms in females with breast cancer. Methods: Sixteen females with breast cancer who referred to radiation oncology centers of Mashhad, Iran, were selected and randomly assigned (with Graph Pad software) into two groups of eight as intervention and control groups .The participants in the pretest, posttest and follow-up (four months) were examined by cognitive emotion regulation questionnaire (CERQ-P) and depression, anxiety and stress scale (DASS-21). Intervention group received eight sessions of two hours (one day per week) of mindfulnessbased cognitive therapy and controls were placed on a waiting list. Data were analyzed by SPSS using multivariate analysis of covariance (MANCOVA). Results:The intervention group showed a significant reduction in the rate of maladaptive cognitive emotion regulation strategies. But no significant differences were observed in the increase of adaptive cognitive emotion regulation strategies and decrease of clinical symptoms between the two intervention and control groups. Conclusions: Mindfulness-based cognitive therapy may be effective to reduce maladaptive cognitive emotion regulation strategies.

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Introduction: Attention deficit hyperactivity disorder (ADHD) is the most prevalent neurodevelopmental disorder among children and adolescents. Given the importance of this disorder, the aim of this study was to investigate the prevalence of ADHD and the relevant factors among the elementary school students in Ardabil, Iran. Methods: Using the stratified random cluster sampling method, this cross-sectional descriptive study was conducted on 2826 schoolchildren aged 6-11 in Ardabil, in the year 2011-2012. The necessary information was collected in the first step employing the ADHD questionnaire based on 18 Diagnostic and Statistical Manual of Mental Disorders-4 th edition (DSM-IV) criteria filled out by parents and teachers. Then the students were interviewed by psychiatrists in the second step. SPSS was used to analyze the research findings. Results: The research results indicated that the lifetime prevalence of ADHD was 9.8%. The most prevalent type of ADHD was the hyperactive-impulsive (6.8%). The results also indicated that the prevalence of ADHD was higher in boys than girls. One-third of affected children were premature at birth and 49.2% had attended kindergartens. The ADHD group was significantly different from the normal students in terms of the average discipline score and the overall grade at school. Conclusion: There is a relatively high prevalence of ADHD in elementary school students; therefore, it is strongly recommended to identify and treat it appropriately in the years prior to school.