Frozen shoulder is among the most prevalent and difficult pathological conditions posed to the orthopedic specialist. It is a disorder characterized by a considerable decrease in the vigorous and passive range of motion (ROM) of the glenohumeral joint and pain. This is a systematic review that was carried out, including PubMed, Google Scholar, and EBSCO, and examined randomized controlled trials, observational, and experimental studies that study pharmacological treatment of the frozen shoulder. The study included 6 studies and concluded that treatment of Frozen Shoulder with steroid is safe and provides better recovery. Previous trials showed that patients treated pharmacologically with corticosteroids either orally or injections are significantly more likely to improve on pain and disability than those treated with physiotherapy only.