Background: Chronic kidney disease (CKD) can adversely affect the respiratory systems functions and dynamics via different mechanisms resulting of toxic metabolites. Patients with CKD require hemodialysis for survival and prior studies have been showed a controversial effects of hemodialysis on respiratory function Objectives: The aim of the study was to investigate the acute impact of hemodialysis on spirometric parameters in patients with CKD undergoing maintenance hemodialysis. Methodology: One hundred patients (50% male, mean age 43.2 ± 15 years) with CKD who underwent regular hemodialysis at the hemodialysis center at Al-Sader Teaching Hospital between January and September 2015were enrolled in the study. Forced expiratory volume in the first second (FEV1), forced vital capacity (FVC) and the FEV1/FVC ratio (FEV1%) were performed for each patient who consented to participate in the study; before the hemodialysis session and within half hour after it. SPSS was used for the statistical analysis. Results: FEV1 and FVC were showed a statistically significant improvement in their values after hemodialysis(P<0.05) while FEV1% showed no significant changes and improvement after hemodialysis(P>0.05). FEV1 and FVC were showed a significant change and increment with increased of the frequency of hemodialysis sessions (P <0.05). Conclusion: There was a significant increase in spirometric parameters after hemodialysis for patients with CKD. Recommendations: A further studies with follow ups are required to confirm our findings and establish the chronic effect of hemodialysis on pulmonary function testAbbreviations: FEV1(Forced expiratory volume in the first second ),FVC( forced vital capacity),CKD(chronic kidney disease),Hb(hemoglobin),GFR(glomerular filtration rate).