The aim of this study was to formulate granisetron (GSN) in a new dosage form using natural substances and to improve pediatric patient compliance to achieve maximum drug efficacy. GSN is a 5HT3 receptor antagonist that used as prophylaxis for prevention of nausea and vomiting before radiotherapy and chemotherapy. This dosage form was selected because of sharing both the advantages of liquid and solid dosage forms. In this study, two types of natural jellifying agents have been used in different concentrations. The natural jellifying agents which have been used were gelatin and caragennan (CRG). The effect of jellifying agent and their concentrations have been investigated. Six formulations of (GSN) oral jellies were prepared by heat and congealing method and the prepared jellies were evaluated by measuring their pH, content uniformity, drug-polymer compatibility, syneresis, physical stability, general appearance and production yield. Among the prepared formulations, formulation F1 with 4.5% gelatin was considered the best one, since it gave the highest drug release 99.4% in 15 min with acceptance results for all other evaluation test.

The aim of present study was to formulate and evaluate oral jellies containing granisetron (GSN). This new dosage form was designed for administration of the drug to specific aged patients (i.e. pediatric) in certain condition. GSN is an antiemetic which is usually used for the treatment of nausea and vomiting induced by radiotherapy and chemotherapy. The selection of this dosage form was based on its acceptability by pediatric population, ease of use and no need for water after taking the dose. In this study, two types of natural jellifying agents have been used in different concentrations. The natural jellifying agents which have been used were pectin and sodium alginate. The effect of jellifying agent and their concentrations have been investigated. Oral jell was prepared by heat and congealing method. Then investigations were done by measuring the pH, content uniformity, syneresis, stability, general appearance and production yield. The investigations showed that the formulation F3 with 5% pectin is the best one.

The aim of present study was to formulate and evaluate oral jellies containing granisetron (GSN). This new dosage form was designed for administration of the drug to specific aged patients (i.e. pediatric) in certain condition. GSN is an antiemetic which is usually used for the treatment of nausea and vomiting induced by radiotherapy and chemotherapy. The selection of this dosage form was based on its acceptability by pediatric population, ease of use and no need for water after taking the dose. In this study, two types of natural jellifying agents have been used in different concentrations. The natural jellifying agents which have been used were pectin and sodium alginate. The effect of jellifying agent and their concentrations have been investigated. Oral jell was prepared by heat and congealing method. Then investigations were done by measuring the pH, content uniformity, syneresis, stability, general appearance and production yield. The investigations showed that the formulation F3 with 5% pectin is the best one.