Autism spectrum disorder (ASD) is one of the most worldwide neurodevelopmental disorders is characterized by the core domains of persistent deficits in social communication and restricted-repetitive patterns of behaviors, interests, or activities and language delay. Pro-inflammatory events and immune system dysfunctions are cellular and molecular events associated with ASD. Several conditions co-occur with ASD: seizures, gastro-intestinal problems, attention deficit, anxiety and depression, and sleep problems. The occurrence of ASD has been increasing worldwide, with the most recent prevalence studies indicating that they are present in 6 per 1000 children. Although the cause of these disorders is not yet known, studies strongly suggest many risk factors have been identified that may contribute to the development of ASDs. These risk factors include genetics, environmental factors, prenatal and perinatal factors, and neuroanatomical abnormalities a genetic basis with a complex mode of inheritance. More research is needed to explore factors that could be contributing to the cause of these disorders. Continued evaluation of genetic factors in combination with these different factors, is critically needed to take this Genetic progress even further in our understanding of, and ability to have a positive impact on, ASD. Inherited factors contribute to ASD etiology, remains incompletely understood. The objectives of this article are to investigate the main cause of ASD provide physicians with relevant information needed to eliminate the incidence of ASD and to eliminate the etiology and management of these disorders. It seemed reasonable to surmise that ABO blood type was functionally related to ASDs. Blood types are inherited from both parents. We hypothesized that if parental ABO blood type were associated with the development of filial ASDs, there would be a higher probability of filial ASDs in parents with a specific ABO blood type. If so, medical workers can .........