No abstract

Hairy cell leukaemia (HCL) is a rare B cell malignancy that is associated with the BRAF V600E mutation and has good treatment response to purine analogues. Its presentation synchronously with other malignancies has been rarely reported. Here, we present a patient with HCL with hepatic involvement who was also found to have pancreatic adenocarcinoma concomitantly at the time of diagnosis. Treating these rare cases simultaneously is a challenge clinically. Throughout this case study, we provide our approach on how oncological care teams provided care for this complicated and rare disease state.

Hemophagocytic lymphohistiocytosis (HLH) has been rarely reported as a complication of anaplastic large cell lymphoma (ALCL), especially in the adult population. We herein present a case of a young woman who presented with multiorgan failure and disseminated intravascular hemolysis and was later found to have ALCL-associated HLH. We also review the current literature on ALCL-associated HLH in adult patients, with their respective treatments and outcomes. We discuss the challenges associated with the diagnosis of lymphoma in the setting of HLH and multiorgan failure. Further, given its high mortality rates, we highlight the importance of promptly identifying and treating the underlying etiology of HLH.