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Gout is an inflammatory condition of the joints caused by deposition of crystallized monosodium urate (MSU) in the joint which leads to Arthritis. there are many debates about the suitable pharmacological therapy for the acute inflammatory gout attacks. The Pharmacological treatment included colchicine, non steroidal anti- inflammatory (NASIDS) and corticosteroid injection. The aim of this study is to review the evidences which studied the effect of Colchicine, NASID and corticosteroid injections and discuss their effectiveness in treating the acute flares of Gout. After evaluation the validity of the latest best evidences presented in the database by using the AMSTAR tool. There was no best drug and no optimal dose identified in treating acute Gout attacks. Doctors should be careful in selecting the treatment considering the side effect of each medication and deal with each patient individually to provide the best health care.

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Background: Pain and sensory abnormalities are the most common abnormalities which could present after lumber disc herniation. However, Recovery of the sensory deficit after decompressive surgery is not clearly defined. Objective: The aim of the current study is to evaluate factors which influence sensory recovery in 12 months after micro-decompression surgery. Patients and methods: This prospective study included 82 patients who subjected to micro-discectomy of lumbar spine in single private hospital in Iraq. We included young and middle age population between 19 and 54 years old and patients who had sensory abnormalities preoperatively and followed up for 12 months postoperatively. Results: Using ROC curve to analyse relationship between age and presence of sensory deficit, there were a sensitivity of 82% and a specificity of 42%. The AUC revealed 0.610 which gives 60% chance to consider the criterion age 37 years in which it might be associated with the worse possible outcome. Using ROC curve to analyse the relationship between duration of radiculopathy and presence of sensory deficit, there was a sensitivity of 85% and a specificity of 51%. The AUC revealed 0.575 which gives 50% chance to consider the criterion duration of more than 300 days in which it might associate with the worse possible outcome. Conclusion: Sensory improvement after micro-decompression surgery needs to be considered with other factors. However, the shorter duration of compression the better the time needed for the nerve to recover. A cut-off value of fewer than 300 days duration of radiculopathy and age less than 37 years old might be considered.

With the use of multi-level features fusion, this work provides a new method for recognizing cognitive brain activity, which we term the Improved Multi-modal cognitive brain-imaging method (IMCBI). Identifying brain areas and basing judgments on insights into intelligent cognitive behavior for babies and adolescents presents a number of methodological issues that the suggested approach seeks to address. In order to understand how the brain functions during various motor, perceptual, and cognitive tasks, IMCBI employs smart methods for fusing data at several levels. This technique employs functional magnetic resonance imaging (fMRI) data to assess human behavioral activity in the brain while engaging in a variety of activities. It does so by combining an inter-subject retrieval strategy with deep neural networks (DNN). The research shows that the suggested method, which uses multi-level fusion of features, greatly raises the accuracy ratio to 95.63 percent, the sensitivity to 95.42 percent, and the specificity to 94.3 three point three percent. The findings demonstrate the method's efficacy in recognizing brain activity based on high-level cognitive ability, making it a useful tool for predicting clinical and behavioral responses.