Background: Recent studies have shown a positive correlation between Inflammatory markers and anorexia in CKD patients, which is a direct contributor to higher hospitalization rates, and higher death rates in hemodialysis patients. In addition, the impairment of renal function exhibits significant alterations in lipoprotein metabolism, which result in the development of severe dyslipidemia, that leads to the development of CVD. Objective: To evaluate the relationship between serum leptin with nutritional inflammatory and cardiovascular risk factors in non-diabetic ESRD Iraqi patients. Subjects & methods: Determination of serum leptin in 51 non-diabetic end stage renal disease patients and comparing it to the serum leptin in 47 healthy controls by ELISA. In addition, determination of serum hsCRP as a most important inflammatory factor, serum albumin and serum cholesterol as nutritional and atherosclerotic factor respectively. Results: serum leptin level is significantly higher in the patient group than the healthy control group (75.9± 23.7 vs 32.5±16.6). In addition, the serum leptin level is positively correlated with serum has CRP level (r = 0.45, p <0.01), serum cholesterol (r = 0.29, p <0.05) respectively. Conclusion: Leptin can be considered as a nutritional and inflammatory marker in non-diabetic ESRD Iraqi patients.