The aim of evaluating the response of rice plant (Anber 33 cultivar) to foliar spraying with single bio- and nano-stimulants with potassium-fortified, A field study was conducted in Al-Tale’a district (41 - Al-Hussainiya) / Babylon province / Iraq. for the period from 15/6/2021 to 23/11/2021.The experiment was implemented according to the Randomized Complete Blocks Design (RCBD), with three replications (48 experimental units) and the experiment included 16 treatments that were randomly distributed to each replicate according to a simple one-way experiment where (7) bioandnano- stimulants were sprayed, represented by Atonikt, Fertigrain, Siaption, Cimfamin BK, Taravertavant, Nano-Optimus plus, and bread yeast (Saccharmyces cerevisiae) individually and fortified with potassium (Tarafol K2O 52%), in addition to the control treatment, spraying with water only, with two sprays for each treatment between one spray and another (14) days. Duncan’s test results showed that foliar spraying with Atonikbiostimulator supplemented with potassium (At+K) scored the highest averages of chlorophyll index (38.87) SPAD, plant height (119.7 cm) and grain yield (3.29) Meg ha-1.Also, foliar spraying with the biostimulantTaravertavant and potassium (Tar + K) achieved the highest significant averages for most of the important traits of the plant, including the biological yield (14.97) Meg ha-1, grain yield (4.31) Meg ha-1, and the weight of 1000 grains (21.23) g. compared with the control treatment, the chlorophyll index was (35.50) SPAD, the plant height was (100.7) cm, the biological yield was (11.13) Meg ha-1, and the grain yield was (3.11) Meg ha-1, the weight of 1000 grains (18.67) g respectively, and the highest agronomic efficiency was achieved when the treatment The dual spraying of potassium-fortified Nano-Optimus plus (Nop+K) was ingested (293.9 kg kg-1).