This study aims to analyze 1) The influence of family environment on students' entrepreneurship knowledge of Islamic Education Management program, 2) The influence of entrepreneurship knowledge on students' entrepreneurship motivation of Islamic Education Management program, 3) The influence of family environment on students' entrepreneurship interest of Islamic Education Management program, 4) Effect of entrepreneurship motivation on students' entrepreneurship interest of Islamic Education Management program, 5) The effect of entrepreneurship knowledge on students' entrepreneurship interest of Islamic Education Management program. The population of this study were students of Islamic Education Management program who have taken entrepreneurship courses. To collect the data, field surveys by distributing questionnaires were conducted. The data obtained were analyzed by using SPSS 16. The results showed that 1) The family environment had a significant effect on students' entrepreneurship knowledge of Islamic Education Management program, 2) Entrepreneurship knowledge had a significant effect on students' entrepreneurship motivation of Islamic Education Management program, 3) The family environment had a significant effect on students' entrepreneurship interest of Islamic Education Management program, 4) Entrepreneurship motivation had a significance influence on students' entrepreneurship interest of Islamic Education Management program, 5) Entrepreneurship knowledge had a significant influence on students' entrepreneurship interest of Islamic Education Management program.