A number of companies have announced the vaccines for COVID-19 pandemic that has caused extreme poverty, famine, and more than a billion people have lost livelihood all across the globe. Mass production of vaccine Sputnik V is underway at different locations to inoculate population in Russia, Philippines, Vietnam, Brazil, Saudi Arab, and United Arab Emirates (UAE), and India. mRNA based vaccine of Pfizer-BioNTech after passing phase 2 trial is ready for testing on thousands of volunteers. Oxford University-AstraZeneca vaccine is also under phase 3 trial in US, Brazil, and India. In September, Novavax Inc.'s vaccine will be ready for phase 3 trial. By early next year, two billions of doses will be ready of Novavax. Moderna Therapeutics conducting vaccine trial on 30 thousands volunteers, results will be known soon. Hundreds of thousand volunteers have registered already for vaccination in US and other parts of the world. SinoVac Biotech Ltd. has prepared a vaccine "CoronaVac" and inoculating volunteers in Indonesia and Brazil. CanSino Biologics Inc. in phase 2 trial on 508 volunteers found a satisfactory immune response to COVID-19 virus. Apart from vaccine preparation and availability, we provided data for therapy and treatment for COVID-19 and transmission and stability aspect of COVID-19 SARS-Cov-2 virus. The data and results presented in this article are very important and useful in containing, treating, and eliminating the pandemic COVID-19.

We have demonstrated the application of the world's fastest supercomputer Fugaku located in Japan to select the COVID-19 drugs and stopping the pandemic spread. Using computer simulation out of 2128 potential drug candidates, the world's fastest supercomputer picked 30 most effective and potential drugs. Twelve of them are under clinical trials outside Japan; some are being tested in Japan. The computer reduced the computation time from one year to 10 days when compared to second superfast computer of the world. Fugaku supercomputer was employed to know the behavior of airborne aerosol COVID-19 virus. 3Cs were suggested: avoid closed and crowded spaces and contacts to stop the pandemic spread. The progress in vaccine development and proper use and type of mask has also been described in this article. The article will benefit greatly to stop spreading and treating the pandemic COVID-19.

The Omicron variant that caused a huge surge in COVID-19 infections worldwide has been studied in terms of prevalence, infectivity, and virulency. The first study conducted in South Africa showed the low pathogenic nature of the Omicron variant compared to the Delta and original Wuhan variants. The deaths, ICU admissions, length of the hospital stay, and also the need of oxygen support all reduced greatly in Omicron infected patients as compared to the earlier variants. The share of the Omicron variant in Delhi (India) rose rapidly. In two weeks (December 21, 2021-January 3, 2022), the omicron prevalence increased from 38% to 81%. Because of the Omicron variant, in the last week of January 2022, Delhi’s caseload surged nine folds. The cases analysed in Delhi, Mumbai, and throughout India revealed that the number of deaths during the Omicron wave was much lower compared to the Delta and Wuhan variants.

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Aerosol transmitted COVID-19 virus (SARS-CoV-2) is infectious causing both symptomatic and asymptomatic infections. The viable COVID-19 virus transmission via air has occurred. Therefore, methods must be established to determine the viability of the virus and to disinfect it in air, surfaces, and on foodstuff. In this review article, we have discussed the pattern virus spread in bus, hospital, and cruise ship. The methods of reducing and eliminating the infection in household and public places have been suggested. The safety, efficacy, and phase 3 trials data published by major vaccine candidates Russian Gamaleya’s “Sputnik V”, Oxford University –AstraZeneca, CanSino Biologics, and Moderna Therapeutics have been included. The article is very useful to stop the COVID-19 pandemic spread and finally ending the pandemic.