Patients who suffered from rheumatic disease and osteoarthritis are generally prescribed the non-steroidal anti-inflammatory drug (NSAIDs). Osteoarthritis is a common musculoskeletal disorder, which impairs body function and acts as an economic burden. Due to the repetitive use of ACE by oral route, it may cause gastrointestinal complications such as ulceration, bleeding, pain, perforation. To decrease the side effects of ACE, it is given by topical route in the form of ointment. This review highlights reducing gastrointestinal problems and promotes the safety and efficacy of the ACE. The Aceclofenac liposomes were prepared by the thin film hydration technique and evaluated by various methods such as in- vitro release study, % yield, drug entrapment efficiency, pH of the prepared formulation. The prepared system was also characterized by Fourier transform infra-red spectrophotometer to identify the drug- excipients interaction. The maximum entrapment efficiency of liposomes was found to be 90%. The main aim of this study was to develop and characterized a vesicular drug carrier system for topical delivery of Aceclofenac to overcome the problem related with oral route. Keywords: Liposomes, Aceclofenac, topical delivery, transdermal delivery, rheumatic disease and osteoarthritis

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This review gives concise information about the application of dendrimers as drug delivery carrier in the field of drug delivery. Due to their unique architecture these have improved physical and chemical properties. Due to their terminal groups these show high solubility, miscibility and reactivity. Dendrimers have well defined size, shape, molecular weight and monodispersity. These properties make the dendrimers a suitable carrier in drug delivery application. Dendrimers are unimolecular miceller in nature and due to this enhances the solubility of poorly soluble drugs. Their compatibility with DNA, heparin and polyanions make them more versatile. Dendrimers, also referred as modern day polymers, they offer much more good properties than the conventional polymers. Due to their multivalent and mono disperse character dendrimers have stimulated wide interest in the field of chemistry biology, drug delivery, gene therapy and chemotherapy. Self-assembly produces a faster means of generating nanoscopic functional and structural systems. But their actual utility in drug delivery can be assessed only after deep understanding of factors affecting their properties and their behaviour in vivo. Keywords: Dendrimers, Drug targeting, nanoscale carriers.