For deworming of horses of drove breeding and wild animals in preserves of free feeding, we have developed an innovative drug based on ivermectin using the technology of mechanochemical modification of ivermectin substance with a mixture of polymers (polyvinylpyrrolidone /PVP/ and arabinogalactan /AG/ Siberian larch Larix sibirica). With this treatment, a solid dispersion of ivermectin (SDI) was obtained in the form of a beige powder, which is easily flowable. The pharmaceutical safety of SDI was studied, the parameters of general toxicity, acute cutaneous toxicity, irritant effects, and the effect of the drug on the eye mucosa were studied. Studies conducted on white mongrel rats. The LD50 of the study drug was found to exceed the test dose. According to GOST 12.1.007-76, the drug belongs to the 4th class of hazard (low hazardous substances). In the study of local irritation of the drug on the skin, it was noted that the integrity of healthy skin on the other hand, where the scratches were not injured, elasticity remained, there was no redness, after a month the sheared layer was healthy. Established the absence of irritating properties of SDI with a single application to the skin. As a result of studying the irritant effect of the drug on the mucous membrane of the eye, it was established that SDI has a moderate local irritant effect on the eyes of animals, estimated at 1 point.

For deworming undomesticated herd horses as well as wild animals in reserves (bison, red deer, wild boars, etc.), an antiparasitic supramolecular complex preparation based on ivermectin and polymers (arabinogalactan and HDPE) was developed in the ratios of wt.%: 2:49:49; it is a light cream powder with particle size 1.0-10 microns, which was obtained using the method of mechanochemistry. When evaluating the parameters of acute and acute cutaneous toxicity, the supramolecular complex of ivermectin administered through the enteric route to white mice and applied to the skin according to GOST 12.1.007-76 belongs to class IV of low toxic substances, and according to the accepted classification (L.I. Medved, 1964), class of substances with subtle accumulation. The supramolecular complex of ivermectin does not have immunotoxic activity. The drug is administered in a mixture with food individually in a prescribed therapeutic dose of 0.15 mg / kg, as well as by the method of group feeding in a mixture with feed compound in a dose of 0.2 mg / kg. Deworming of herd horses with a preparation to be used in a mixture with food is technically convenient and practically not difficult, while excluding physical stress during fixation of animals, and industrial injuries. No side effect is observed after deworming.