Environmental contamination with a variety and mixed pollutants are a problematic issue worldwide. If the contaminated sites are left without any satisfactory remediation, it leads to the successive threaten of ecosystems, then human life. So, applications of nanotechnology in environmental remediation are encouraged because of the novel properties (e.g. special structure, very large surface area and greater reactivity), whereas, ''Nano'' may be more than just ''small''. Also, environmental nanotechnology restraint is due to lack of full understanding characterization, fate and transport of such ultrafine materials in the environment. The objective of this work is to point major challenges facing environmental nanoscience and urges developing eco-friendly techniques to ensure good quality of life.