Paraquat is an environmental pollutant that is associated with some disorders including alteration of some harmatological indices and is a concern to public health. Vitamin E has antioxidant property and other characteristic roles that ameliorate toxic effect. 200 male albino rats weighing 0.2±0.02kg on the average were divided into four main groups (A, B, C, and D) with 50 rats in one group. The “A” group was not served paraquat solution and was used as the control group. Group “B”, “C”, “D” being the treatment group were given dose rates of paraquat of 0.02g, 0.04g, and 0.06g, of paraquat per kg rat respectively every two weeks for three months. The main groups further had subgroups. “A”, “A0” and “AVE”; “B”, “B0” and “BVE”; “C” had “C0” and “CVE”; and “D”, “D0” and “DVE” subgroups. Vitamin E was not given to subgroups “A0”, “B0”, “C0” and “D0” subgroups while “AVE”, “BVE”, “CVE” and “DVE” were fed orally with 500mg of vitamin E therapy every week. Treatment with vitamin E began three months after paraquat treatment. At the end of the weekly treatment with vitamin E for a month, the rats were sacrificed and their blood samples were obtained and analyzed for PCV, Hb, WBC, neutrophil and lymphocyte. A0, B0, C0 and D0 intergroup comparison was statistically significant, p-value<0.05 in PCV and Hb levels while their WBC, neutrophil and lymphocyte had no statistical significance. Ave, Be, Cve and Dve intergroup comparison was statistically significant, p-value<0.05 in PCV and Hb levels while WBC, lymphocyte and neutrophils had no statistical significance among the groups. Intra group comparison showed that only PCV and Hb were significant between groups, p-value<0.05. This study confirms that vitamin E is potent in treating paraquat toxicity in male albino rats on one month of weekly treatment.
Soot is known as unwanted by-products gotten from incomplete burning of materials that contain carbon. Soot is also known as black carbon (BC) or carbon blacks (CBs). It is capable of causing many health issues in both humans and animals. When illegal refining and burning activities are carried out, the end product is usually the production of soots. Cases of soot emissions rising in developing countries. It is one cause of diseases in the human population; these diseases include respiratory diseases, cardiovascular diseases, cancers, and sometimes reproductive system abnormality. Rivers State is a highly populated State with lots of companies carrying out one form of refining and exploration or another. Two factors are responsible for the rising increase of soot in Rivers State, the burning of illegal petroleum product by security agencies and the operation of unlawful illegal refineries carried out from the creeks and surroundings of some local communities and Port Harcourt, the State headquarters. The aim of this review was to assess the effects soot has on the haematological parameters of individuals living in Rivers State. Soot has been shown by several studies to cause some deviation in the haematological parameters such as decrease in the PCV, Hb and RBC. However, it also brings about an increase in the total white blood cell count, neutrophils and lymphocytes. This review provides information on the haematological insults associated with soot exposure in Rivers State.
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