Objective: To systematically evaluate the risk factors of liver damage in newly diagnosed patients with hyperthyroidism and provide a clinical basis for the diagnosis and treatment of liver injury in hyperthyroidism. Methods: Pubmed, Embase, The Cochrane Library, CNKI, VIP and other databases were searched to collect the risk factors of hepatic damage in newly diagnosed hyperthyroidism patients published up to May 2020. Library until May 2020. Two researchers independently screened the literature, extracted data, and evaluated the risk of bias in the included studies, and Meta-analysis was performed by RevMan 5.3 software. Results: A total of 18 documents were included, with a total of 2637 cases and 1884 controls. Meta-analysis results show: age, course of disease, thyroid weight, FT4, TRAb, TGAb, TPOAb are all risk factors for hepatic injury in newly diagnosed patients with hyperthyroidism. Conclusion: While age, course of disease, thyroid weight, FT4, TRAb, TGAb and TPOAb are risk factors for liver damage in newly diagnosed patients with hyperthyroidism, gender has nothing to do with them.

BackgroundThe present study was conducted to analyze possible risk factors in patients with type 2 diabetes who are in hypoglycemic coma.Material/MethodsA total of 194 patients with type 2 diabetic hypoglycemic coma who were admitted to our hospital between January 2010 and January 2016 were included. The patients were all in coma on admission, and their blood glucose levels were lower than 2.8 mmol/L. None of the patients had type I diabetes, specific types of diabetes, or gestational diabetes. Multiple linear regression analysis was used to determine possible factors associated with hypoglycemic coma.ResultsAmong the patients, 82 were male and 112 were female (mean age, 66.88±10.62 years). In addition, 72 patients lived in urban areas and 122 lived in rural areas. Occurrence of hypoglycemic coma was correlated with difference between urban and rural residence, glycosylated hemoglobin (HbA1c) level, combined hypertension, and combined neural complications. Self-purchased drugs resulted in significantly lower blood glucose level at the onset of hypoglycemic coma than insulin, secretagogue, or non-secretagogue drugs. Blood glucose level at onset was correlated with season. Patients living in rural areas or with combined macrovascular or microvascular complications had prolonged hospital stay and poor prognosis.ConclusionsOur results demonstrate that rural residence, higher HbA1c level, combined hypertension, and combined neural complications increase the incidence of hypoglycemic coma. Use of self-purchased drugs and colder seasons may result in lower blood glucose levels in patients with hypoglycemic coma.

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