Tumor hypoxia and systemic toxicity seriously affect the efficacy of photodynamic therapy (PDT) and are considered as the “Achilles’ heel” of PDT. Herein, to combat such limitations, an intelligent orthogonal emissions LDNP@SiO2‐CaO2 and folic acid‐polyethylene glycol‐Ce6 nanodrug is rationally designed and fabricated not only for relieving the hypoxic tumor microenvironment (TME) to enhance PDT efficacy, but also for determining the optimal triggering time through second near‐infrared (NIR‐II) fluorescence imaging. The designed nanodrug continuously releases a large amount of O2, H2O2, and Ca2+ ions when exposed to the acidic TME. Meanwhile, under downshifting NIR‐II bioimaging guidance, chlorine e6 (Ce6) consumes oxygen to produce 1O2 upon excitation of upconversion photon. Moreover, cytotoxic reactive oxygen species (ROS) and calcium overload can induce mitochondria injury and thus enhance the oxidative stress in tumor cells. As a result, the NIR‐II bioimaging guided TME‐responsive oxygen self‐sufficient PDT nanosystem presents enhanced anti‐tumor efficacy without obvious systemic toxicity. Thus, the fabricated nanodrug offers great potential for designing an accurate cancer theranostic system.

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Motivated by the increasing demands on the precision of 3D large-scale measurement, the extrinsic parameters calibration with high accuracy of the bistatic non-orthogonal shafting laser theodolite (N-theodolite) system is required. A two-step method is proposed to achieve the extrinsic parameters calibration with high accuracy in this paper. In the first step, by analyzing and setting the approximate emitted point during the motion of the laser axis in local space, the calculation of the initial extrinsic parameters can be simplified. In the second step, the above results are taken as the initial values of optimization, and the distances between the spatial laser points provided by PSD sensors with high accuracy in global space are used to construct the unconstrained optimal objective function. The proposed method is validated with the measurement experiment of the bistatic N-theodolite system, the average error of 3D coordinate measurement is less than 0.4 mm, and the average error of distance measurement is less than 0.3 mm within 5 m.

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