The main aim of this research was to study the influence of sweet potato powder on diabetic rats. A total of 24 adult male albino rats of "Sprague Dawley" strain (150 ±5g) were used and randomly divided into 4 equal groups including negative control group, positive control group, while the other two groups were treated with 10% raw potato and 30% cooked potato depending on sensory evaluation of biscuits supplemented with raw and cooked sweet potato powder. The experiment lasted for 28 days. Measurements included determining glucose, liver functions, kidney functions and lipid profile in serum and pancreas histopathology. The results indicated that induced alloxan resulted in significant increases in glucose in urine and serum, in addition to a significant increase in liver and kidney functions, lipid profile expect HDL-C were decreased compared with a negative control group and abnormal histopathological changes were noticed in pancreas dysfunction resulted from abnormal histopathology was observed. Like raw and cooked sweet potato induced anti-diabetic effects and decreased glucose in blood serum. Moreover, they alleviated alloxan-induced abnormalities in body weight, liver and kidney functions. Accordingly, this study recommends diabetic patients to regularly consume sweet potato and its leaves with a suitable dose since they can induce an improvement in increase blood sugar.