Background: Chemerin is a novel adipokine that has been found to function in both autocrine and paracrine pathways. It draws in both innate and adaptive immune cells as a chemoattractant. There are several roles for this pro-inflammatory chemokine. Also called retinoic acid receptor responder 2 (RAR2) and tazarotene-induced gene 2 (TIG2). The protein chemerin is involved in a variety of processes, including metabolism, inflammation, and adipogenesis, as well as vascular dysregulation. Chemerin was evaluated among different inflammatory skin diseases and showed significant correlations. Objective: Review of the biological role of chemerin in inflammatory skin disease. Methods: We looked for data on Chemerin, Biological role and Inflammatory skin disease in medical journals and databases like PubMed, Google Scholar, and Science Direct. However, only the most recent or extensive study was taken into account between February 2015 and January 2023. References from related works were also evaluated by the authors. There are not enough resources to translate documents into languages other than English, hence those documents have been ignored. It was generally agreed that documents such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations did not qualify as legitimate scientific study. Conclusion: Psoriatic individuals had increased chemerin levels in their skin biopsies. Also serum chemerin levels were found to increase with acne vulgaris disease severity. Recent research has found a correlation between obesity and atopic dermatitis, an inflammatory skin condition. Adipokines can be used as a marker for the degree to which eczema is present.