The fabrication of single‐molecule white‐light emission (SMWLE) materials has become a highly studied topic in recent years and through‐space charge transfer (TSCT) is emerging as an important concept in this field. However, the preparation of ideal TSCT‐based SMWLE materials is still a big challenge. Herein, we report a bifunctional pillar[5]arene (TPCN‐P5‐TPA) with a linear donor‐spacer‐acceptor structure and aggregation‐induced emission (AIE) property. The bulky pillar[5]arene between the donor and acceptor induces a twisted conformation and a non‐conjugated structure, resulting in intramolecular TSCT. In addition, the AIE feature and pillar[5]arene cavity endow TPCN‐P5‐TPA with responsiveness to viscosity and polar guests, by which the TSCT emission is triggered. The combination of blue locally‐excited state emission and yellow TSCT emission of TPCN‐P5‐TPA generates SMWLE. Therefore, we provide a new and versatile strategy for the construction of TSCT‐based SMWLE materials.

Dysregulation of microRNAs frequently contributes to the occurrence and progression of human diseases, including hepatocellular carcinoma (HCC). In this study, the role of miR‐450b‐3p in HCC was investigated. Gene Expression Omnibus database and HCC specimens were used to evaluate the expression level of miR‐450b‐3p and the patient's prognosis. Cell functional analyses and tumor xenograft model were used to assess the role of miR‐450b‐3p in HCC. Bioinformatics was used to predict the downstream target gene of miR‐450b‐3p, which was verified by dual‐luciferase reporter assay. MiR‐450b‐3p was found to be downregulated in HCC cell lines and tissues, compared with nontransformed immortal hepatic cells and adjacent normal liver tissues, respectively. Lower expression of miR‐450b‐3p was associated with poor overall survival and disease‐free survival in patients with HCC. Ectopic expression of miR‐450b‐3p inhibited HCC cell viability, colony formation, and cell‐cycle progression in vitro, and suppressed the growth of HCC xenograft tumors in vivo. Interestingly, a negative correlation between miR‐450b‐3p and phosphoglycerate kinase 1 (PGK1) protein was observed among HCC specimens. Additionally, miR‐450b‐3p inhibited PGK1 expression and phosphorylation of protein kinase B in HCC cell lines. Further experiments confirmed that PGK1 was a direct target of miR‐450b‐3p. Moreover, restoration of PGK1 abrogated the inhibitory effect of miR‐450b‐3p on HCC proliferation and cell division. In conclusion, miR‐450b‐3p is downregulated in human HCC and exerts tumor suppressive effects at least in part by inhibiting PGK1.

Chemoresponsive supramolecular systems with infinite switching capability are important for applications in recycled materials and intelligent devices.T oa ttain this objective,h ere ac hemoresponsive polypseudorotaxane is reported on the basis of ab is(p-phenylene)-34-crown-10 macrocycle (H)a nd ac yano-substituted viologen guest (G). H and G form a[ 2]pseudorotaxane (H'G)b oth in solution and in the solid state.Upon addition of AgSF 6 ,apolypseudorotaxane (denoted as [H•G•Ag] n )f orms as synergistically driven by host-guest complexation and metal-coordination interactions.[ H•G•Ag] n depolymerizes into a[3]pseudorotaxane (denoted as H 2 •G•Ag 2 •acetone 2 )u pon addition of H and AgSF 6 ,w hile it reforms with successive addition of G.T he transformations between [H•G•Ag] n and H 2 •G•Ag 2 •acetone 2 can be switched for infinite cycles,superior to the conventional chemoresponsive supramolecular polymeric systems with limited switching capability.