Pyrano[3,coumarin derivatives and C3-substituted 4-hydroxycoumarins as important skeletal structures of active natural products and pharmaceutically relevant molecules have received increasing attention. However, developing an adjustable system for selectively synthesizing them is still a challenging task. Herein, sulfonic acid-functionalized ionic liquid was successfully used as the catalyst for the alkylation of 4-hydroxycoumarin derivatives with secondary aromatic propargylic alcohols using dimethyl carbonate as the green solvent, giving up to 98% yield. On the other hand, protonated imidazole-based ionic liquidcatalyzed cyclization was also selectively achieved with a nearly quantitative yield. Developed metal-free catalytic systems exhibited well adjustable and recyclable properties, avoiding the contamination of metal and halogen, reducing the neutralization after the reaction, and benefiting the separation between the catalyst and the product. New strategies were applied for performing the gramscale reaction smoothly. The adjustable systems might occur through two different mechanisms involving propargylic or allenic carbocation and hydrogen bonding effects between the catalysts and the substrates.
One of the ultimate goals in organic synthesis is to develop metal‐free, efficient and easily separable catalytic system for atom economic organic reactions in an environmental solvent. Direct substitution reaction of alcohols and hydrocarbon compounds is a significant and atom economic method for C−C bond formation. Herein, a metal‐free and efficient catalytic system including recyclable pyridine‐based ionic liquids with multiple active sites as the catalyst and dimethyl carbonate as the environmentally friendly solvent was developed for atom economic C3 substitution of 4‐hydroxycoumarins with alcohols. Primary aromatic alcohols, secondary aliphatic and aromatic alcohols were suitable for the reaction, providing up to 99 % yield. The catalytic system could be easily scaled up to gram‐scale with nearly quantitative yield. Coumatetralyl as commercial rodenticide could be prepared directly from commercially available 4‐hydroxycoumarin and 1,2,3,4‐tetrahydronaphthalen‐1‐ol. Racemic product derived from the reaction of (R)‐1‐phenylethanol and 4‐hydroxycoumarin indicated the reaction was achieved through an SN1 pathway. The comparison of the activities and acidities of the ionic liquids demonstrated that there was no directly relationship between them. Control experiments showed that the reaction probably proceeded via carbocation, ether intermediate and synergistically promoted effect of hydrogen bonding between the ionic liquid with multi‐active sites and substrates.
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