Objective The aim of this study is to characterize the demographics, fibromyalgia-related symptom severity and quality of life (QOL) among Chinese fibromyalgia patients. Methods A total of 124 patients who met the ACR 1990 criteria were recruited. Each subject completed a packet of questionnaires for collecting data on the demographics, medical history and severity of six major symptoms of fibromyalgia (i.e., pain, fatigue, sleep quality, depression, stress and QOL). Results The majority of the study subjects were women (86.3%), were married (78.2%) and had a mean age of 49.4 years and a median symptom duration of 24 months. Compared to their female counterparts, male patients were younger, were more likely to be employed, had a higher income and were more likely to be current smokers and alcohol drinkers (all p ≦ 0.027). Most patients experienced moderate to severe pain (69.4%), severe fatigue (70.2%) and moderate to severe depression (53.3%). A small percentage (19.4%) of the patients had very poor quality of sleep, and over one third (37.1%) suffered from moderate to severe stress. Less than one third (27.5%) patients’ health status was moderately or highly impacted by fibromyalgia. The mental health of men was affected significantly more than that of women, with lower SF-36 scores in the SF-36 mental component summary ( p = 0.043) and role emotional ( p = 0.006). Conclusion This study has revealed that Chinese fibromyalgia patients might share similar demographics but milder fibromyalgia-related symptoms and better mental QOL compared to patients of other races and ethnic groups. Some differences between male and female patients were found, too. Further cross-sectional studies with a larger sample size and nationwide study sites are needed to replicate those clinical findings.

AimThe aim of the study was to observe the effect of acupuncture on regulating interleukin (IL)‐17, tumor necrosis factor (TNF)‐ɑ, and aquaporins (AQPs) in Sjögren's syndrome (SS) on patients and on non‐obese diabetic (NOD) models.MethodsLevels of anti‐AQP 1, 5, 8, and 9 antibodies, IL‐17, and TNF‐ɑ in the serum of SS patients were compared prior and following 20 acupuncture treatment visits during 8 weeks. While in murine model, five groups were divided to receive interventions for 4 weeks, including control, model, acupuncture, isoflurane, and hydroxychloroquine. The submaxillofacial gland index, histology, immunohistochemistry of AQP1, 5, salivary flow, together with IL‐17, and TNF‐ɑ expression in peripheral blood were compared among the groups.ResultsAcupuncture reduced IL‐17, TNF‐ɑ, and immunoglobin A levels, and numeric analog scale of dryness in 14 patients with SS (p < 0.05). The salivary flow was increased, and the water intake decreased in NOD mice receiving acupuncture treatments. IL‐17 and TNF‐ɑ levels in peripheral serum were down‐regulated (p < 0.05) and AQP1, 5 expression in the submandibular glands up‐regulated in mice.ConclusionThe effect on relieving xerostomia with acupuncture may be achieved by up‐regulating the expression of AQP1. AQP5, down‐regulating levels of IL‐17 and TNF‐ɑ, and a decrease in inflammation of glands.

Review question / Objective: We will search, with no time restrictions, electronic databases, contact with authors, trial registers, or grey literature. Condition being studied: Diabetic foot ulcers (DFU) are one of the serious complications of diabetes; these ulcers develop in about 15-25% of patients with d i a b e t e s. I n a d d i t i o n , 2 8 %-8 9 % o f amputations performed for nontraumatic INPLASY 1